background: n-acetylcysteine (nac) has been indicated against experimental seizures, but with relatively inconclusive results. this study was undertaken to evaluate whether nac exerts a dose-dependent anticonvulsant effect and to determine nac safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses. methods: following intraperitoneal (i.p.) administration of ...

stachys lavandulifolia is used as the herbal tea and its wide and potent medical effects have been reported for the extract in animal studies. this study aimed to find the safety profile of the extract to find the appropriate doses for further human studies. the aerial parts of the plant were air-dried and the hydroalcoholic extract was obtained and concentrated by percolation method with 140 m...

pesticides are widely used in iranian agriculture and this has made a major toxicological concern among health professionals. the objective of this study is to explore national data about pesticides toxicity. all relevant databases such as google scholar, pubmed, and scopus in a time period of 1960 to 2012 were searched for the keywords “pesticides, iran, environment, and population studies”. a...

Arsenic toxicity is a global health problem affecting many millions of people. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Arsenic is present as a contaminant in many traditional remedies. Arsenic trioxide is now used to treat acute promyelocytic leukaemia. ...

background and objectives: salvia chloroleuca rech. f. & allen., is an endemic species growing wildly in north east and center parts of iran but there is no information about its safety. to provide information about the safety of the species, we evaluated its acute and sub chronic toxicity in rats. methods: in acute toxicity study, the aqueous methanol (80%) extract at a single dose of 2000...

teucrium polium l. (tp) is widely used in traditional medicine of many countries including iran. there are various reports about pharmacological properties of tp such as calcium antagonist, anti- ulcer, anti – diabetic. there are a few reports about possible toxicological effects of this plant. in the present study we designed to evaluate the subchronic toxicity of teucrium polium total extract...

objective(s) ocimum basilicum l. is widely used in folk medicine of many countries including iran. both o. basilicum and its oil extract have received considerable attention for their potential medicinal properties, but there are a few reports about possible toxicity of this plant. therefore, in the present study, acute and subchronic toxicity of o. basilicum hydroalcohlic extract have been eva...

in iranian folk medicine, especially in west of the country, the aromatic water of rheum ribes has been used for several purposes such as fever reduction.  despite the widespread use of this plant as food or as a medicinal plant, there is still lack of information on its toxicity profile.                                                                in the present study we aimed to evaluate th...

cyclizine (1-benzhydryl-4-methyl-piperazine, cas 82-92-8, cyc, i), a piperazine derivative, belongs to h1 antihistamine group of drugs that shows such pharmacological properties as anti-inflammatory, anti-allergic and anti-platelet effects, similar to other h1-receptor antagonists. in this study, two new tolyl and cumene derivatives of i (1-ethyl-4-[(p-isopropylphenyl) (p-tolyl) methyl]-piperaz...

Background: N-acetylcysteine (NAC) has been indicated against experimental seizures, but with relatively inconclusive results. This study was undertaken to evaluate whether NAC exerts a dose-dependent anticonvulsant effect and to determine NAC safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses.Methods: Following intraperitoneal (i.p.) administration of N...