Acute disseminated encephalomyelitis is a demyelinating disease, typically occurring in children following a febrile infection or a vaccination. Primary and secondary immune responses contribute to inflammation and subsequent demyelination, but the exact pathogenesis is still unknown. Diagnosis of acute disseminated encephalomyelitis is strongly suggested by temporal relationship between an inf...

Binary combinations of the N-nucleoside ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) and the C-nucleoside analog selenazofurin (2-beta-D-ribofuranosylselenazole-4-carboxamide) or tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide) were tested in vitro for activity against Venezuelan equine encephalomyelitis, Japanese encephalitis, yellow fever, Rift Valley fever, Korean...

Distinction between acute disseminated encephalomyelitis and acute multiple sclerosis is often clinically difficult. Perivenous demyelination is the pathological hallmark of acute disseminated encephalomyelitis, whereas confluent demyelination is the hallmark of acute multiple sclerosis. We investigated whether perivenous demyelination versus confluent demyelination distinguishes acute dissemin...

how to cite this article: inaloo s, haghbin s, moradi m, dashti h, safari n. acquired cns demyelinating syndrome in children referred to shiraz pediatric neurology ward. iran j child neurol. 2014 spring; 8(2):18-23. objective incidence of cns acquired demyelinating syndrome (ads), especially multiple sclerosis (ms) in children, appears to be on the rise worldwide. the objective of this study wa...

The recent article on acute demyelinating encephalomyelitis in a patient with falciparum malaria is very interesting [1]. Indeed, the neurological complication of falciparum malaria is not uncommon but the acute demyelinating encephalomyelitis is extremely rare. Recently, a similar case was published in another journal [2]. It was proposed that the pathophysiology is due to immunopathological p...

Acute disseminated encephalomyelitis is an immune-mediated inflammatory demyelinating disorder of the central nervous system. The first-line treatment is usually high-dose intravenous methylprednisolone. Intravenous immunoglobulin and plasmapheresis have also shown to be beneficial. Immunosuppressive agents like cyclophosphamide have been used in adults with fulminant acute disseminated encepha...

The initial presenting clinical and laboratory findings of either acute disseminated encephalomyelitis or the first attack of multiple sclerosis in the pediatric population were compared and contrasted. A retrospective review of the medical records was conducted of all children younger than 17 years who presented with either the diagnosis of acute disseminated encephalomyelitis or multiple scle...

Acute disseminated encephalomyelitis is an acute autoimmune demyelinating disease that manifests as a widespread polyfocal asymmetric lesions of the central nervous system and, in some cases, optic nerves with formation corresponding neurological symptoms. This lecture presents basic information about consideration 5 clinical cases demonstrating variety manifestations this practice neurologist.

introductio dengue fever is the world’s most important hemorrhagic fever, especially in america, pacific islands, and asia. in countries like ours where viral hepatitis, malaria, enteric fever are common; it represents a challenge to identify the etiology of acute fever complicated by hepatitis. case presentation we report a case of acute hepatitis in a 7-year-old male with dengue hemorrhagic f...