PURPOSE To evaluate the outcome of liver transplantation for acute-on-chronic liver failure. PATIENTS AND METHODS From November 1991 to December 2007, 517 patients underwent liver transplantation at Queen Mary Hospital, Hong Kong. Among them, 149 had acute-on-chronic liver failure as defined in the recent Asian Pacific Association for the Study of Liver Consensus Meeting. Their clinical data ...

Introduction Acute liver failure is a fatal syndrome attributed to massive hepatocyte apoptosis that is resistant to conventional medical therapies. Consequently, liver transplantation is required in many cases. An experimental liver failure model induced by galactosamine (Gal) and lipopolysaccharide (LPS) mimics clinical acute liver failure. In this model, LPS stimulates macrophages to release...

Acute liver failure in children is associated with a high mortality. Most cases in our setup are due to water borne hepatotropic viruses HAV and HEV. The clinician must be aware of the earliest and the subtle signs of acute liver failure to identify cases early enough and institute supportive therapy. Focus of therapy has to be on prevention, early recognition and appropriate management of comp...

Acute liver failure (ALF) (sometimes referred to as fulminant hepatic failure) is a clinical syndrome from a variety of causes resulting from rapid loss in hepatocyte function, typically associated with coagulopathy and encephalopathy in a patient without preexisting liver disease or cirrhosis. Cerebral edema is a cardinal feature and may produce uncal herniation, yielding brain stem compressio...

Acute liver failure is a rare but often catastrophic illness affecting the liver and multiple organ systems. Patients with acute liver failure require a multidisciplinary approach for adequate management. With improved critical care and the availability of liver transplantation, survival has significantly improved. Hepatic encephalopathy, cerebral edema and infections are the most common compli...

Acute liver failure (ALF) is a progressive life-threatening condition characterized by hepatic dysfunction with coagulopathy and hepatic encephalopathy (HE) that evolves over a few days or weeks. Besides development of HE, ALF results in development of multi-organ failure (MOF), and is still associated with a ~40% mortality risk depending on the etiology and severity of liver injury. The progno...

Hospital Physician July/August 2009 A 45-year-old Hispanic woman with a history of systemic lupus erythematosus, depression, recurrent pyelonephritis, pancreatitis, cholecystectomy, and chronic abdominal pain was admitted to a community hospital for worsening abdominal pain. She had previously been prescribed hydrocodone bitartrate/acetaminophen for chronic abdominal pain. Preoperative laborato...

Acute liver failure refers to the rapid development of severe acute liver injury with impaired synthetic function in a patient who previously had a normal liver or a well compensated liver disease. Its aetiology is diversified and it provides one of the best indicators of prognosis thus being crucial its quick identification. Because it can progress to multiple organ failure syndrome these pati...

Copyright © 2013 Massachusetts Medical Society. A cute liver failure is a rare but life-threatening critical illness that occurs most often in patients who do not have preexisting liver disease. With an incidence of fewer than 10 cases per million persons per year in the developed world, acute liver failure is seen most commonly in previously healthy adults in their 30s and presents unique chal...

BACKGROUND/AIMS To present the causes of acute liver failure in Turkey. MATERIALS AND METHODS [corrected] International and national medical research databanks were searched for publications related to acute liver failure and originating from Turkey. Patients in the databank of acute liver failure of our center were also added to this literature search. Patients were evaluated for age, gender...