Our findings demonstrate the pivotal importance of caspase-3 in regulating renal microvascular dysfunction, fibrogenesis, and long-term impairment after acute kidney injury induced by ischemia-reperfusion injury. Furthermore, this study establishes predominant role peritubular capillary integrity as a major contributor to progressive dysfunction

Introduction. Acute kidney injury is a serious complication in critically ill patients the intensive care units. The incidence varies from 20% to as high 80%. associated with expensive supportive therapy, morbidity and poor outcomes. aim of this study was determine incidence, causes, risk factors, treatment options outcomes acute patients. Material Methods. included 44 patients, an average age ...

 ABSTRACT COVID-19 mainly affects respiratory and immune systems, but other organs like renal, cardiovascular, lung and nervous systems could also be involved in both acute and chronic settings (1, 2). There is a lot of studies that demonstrate an increasing number of long COVID-19 who continue to experience persistent symptoms weeks or even months after the initial disease. Reports suggest...

background renal ischemia reperfusion (ir) contributes to the development of acute renal failure (arf). oxygen free radicals are considered principal components involved in the pathophysiological tissue alterations observed during renal ir. objective in this study, we compared the effects of melatonin (mel) and erythropoietin (epo), which are known antioxidant and anti-inflammatory agents, in i...

renal ischemia-reperfusion (ir) contributes to the development of acute renal failure (arf). oxygen free radicals are considered to be principal components involved in the pathophysiological tissue alterations observed during renal ir. the purpose of this study was to investigate the combination effect of melatonin (mel) and erythropoietin (epo), which are a potent antioxidant and anti-apoptoti...

Objective: Effects of cotreatment with Urtica dioica (UD) methanolic leaf extract on gentamicin (GM)-induced acute kidney injury were evaluated in rats. Materials and Methods: Male Wistar rats (n=32) were separated into four groups. Gentamicin (100 mg/kg/day, IP) was injected for eight days with or without UD methanolic extract (200 mg/kg/day, gavage). Th...

BACKGROUND Acute kidney injury occurs commonly in hospitalized patients and is associated with significant morbidity and mortality. Although renal ultrasound is often performed, its clinical utility in determining of the cause of acute kidney injury, particularly the detection of urinary tract obstruction, is not established. METHODS Retrospective cohort study of all adult inpatients that und...