INTRODUCTION ADAM33 is the candidate gene most commonly associated with asthma and airway hyperreactivity (AHR). AIM The aim of this study was to determine whether level of AHR is associated with certain alleles or haplotypes of the ADAM33 gene in asthmatic children. METHODS One hundred and nine asthmatic children and 46 controls from the general population were examined with spirometry bef...

OBJECTIVE To study the association between ADAM33 and keloid scars in the northeastern Chinese population. METHODS A total of 283 keloid scar patients and a control group of 290 healthy volunteers were recruited for this study. Six polymorphic loci (V4, T+1, T2, T1, S2 and Q-1 ) of ADAM33 were selected for genotyping. Genotypes were determined by using the polymerase chain reaction-restrictio...

BACKGROUND The influence of asthma candidate genes on the development from wheeze to asthma in young children still needs to be defined. OBJECTIVE To link genetic variants in asthma candidate genes to progression of wheeze to persistent wheeze into childhood asthma. MATERIALS AND METHODS In a prospective study, children with recurrent wheeze from the ADEM (Asthma DEtection and Monitoring) s...

Allergic rhinitis is a chronic inflammatory disease that is assumed to be due to an interaction between different genetic and/or environmental factors. A disintegrin and metalloprotease domain 33 (ADAM33) has been extensively studied as a susceptibility gene in asthma and has been linked to bronchial hyper-responsiveness. In this study, we investigated the association between ADAM33 single nucl...

BACKGROUND The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis. OBJECTIVE To assess whether the ADAM33 polymorphisms are associated with persistent allergic rhinitis (PER) due to house dust mites in a Chinese population. METHODS In a hospital-based case...

To dissect the role of immunogenetics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children selected from a cross-sectional study conducted using ISAAC (International Study of Asthma and Allergies in Children) Phase II tools. We investigated 9 loci involved in different immune functions (ADAM33, ADRB2, CD14, IL13, IL4, IL4R, MS4A2, SERPINE1, and TNF) with ...

BACKGROUND Variation in ADAM33 has been shown to be important in the development of asthma and altered lung function. This relationship however, has not been investigated in the population susceptible to COPD; long term tobacco smokers. We evaluated the association between polymorphisms in ADAM33 gene with COPD and lung function in long term tobacco smokers. METHODS Caucasian subjects, at lea...

OBJECTIVES Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. MATERIALS AND METHODS This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM33 gene have been assessed in patients with allergic asthma and normal contro...

Disintegrin and metalloprotease 33 (ADAM33) have been associated with childhood and adult asthma in many populations. ADAM33 mutations might predispose to altered lung function in early infancy. In this study, we investigated the association between single-nucleotide polymorphisms in ADAM33 and the incidence of adult and childhood asthma among Jordanians. One hundred seven pediatric asthmatic p...

objective(s): asthma results from the interaction between genetic and environmental factors. adam33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. materials and methods: this is a case-control study, where four snps s1 (rs3918396), t1 (rs2280091), t2 (rs2280090), v4 (rs2787094) of adam33 gene have been assessed in patients with allergic asthma and normal cont...