Diffusion- and perfusion-weighted magnetic resonance imaging (DWI and PWI) was applied for stroke diagnose in 120 acute (< 48 h) ischemic stroke patients. At hyperacute (< 6 h) stage, it is difficult to find out the infarction zone in conventional T1 or T2 image, but it is easy in DWI, apparent diffusion coefficient (ADC) map; when at 3-6-hour stage it is also easy in PWI, cerebral blood flow (...

Therapies targeting the mitogen-activated protein (MAP) kinase pathway in melanoma have produced significant clinical responses; however, duration of response is limited by acquisition of drug resistance. Rational drug combinationsmay improve outcomes in this setting.We assessed the therapeutic combination of an antibody–drug conjugate (ADC) targeting the endothelin B receptor (EDNRB) with smal...

L. Ma, K. Zheng, W. Sun, H. Lu, Y. Wang Department of Radiology, PLA General Hospital, Beijing, China, People's Republic of, Department of Radiology, Navy General Hospital of PLA, Beijing, China, People's Republic of, GE Healthcare China, Beijing, China, People's Republic of Although there are some technical difficulties in applying diffusion tensor imaging (DTI) in the spinal cord, DTI has bee...

PURPOSE To establish the utility of apparent diffusion coefficient (ADC) entropy in discrimination of benign and malignant adnexal lesions, using histopathology as the reference standard, via comparison of the diagnostic performance of ADC entropy with mean ADC and with visual assessments of adnexal lesions on conventional and diffusion-weighted sequences. MATERIALS AND METHODS In all, 37 adu...

Introduction Choroidal melanoma is the most common intraocular malignancy . Diffusion weighted MRI (DWI) and the derived apparent diffusion coefficient (ADC) map has proven to be useful in tumor identification and treatment response monitoring . However, DWI of intraocular tumor, such as choroidal melanoma, has not been reported to date. The objective of the present study is to quantify ADC of ...

and negative (red) bipolar gradients results in cancelling contributions from off-diagonal diffusion tensor elements to the DW signal. Figure 2: A. Trace weighted MRIs acquired using our ssTW method in 15s across the entire brain. B. Brain tissue regions-of-interest (ROIs) C. Mean ADC map calculated from the ssTW scan. D. Mean ADC map calculated using DTI with 20 directions in 2 min. E. Directi...

Fig. 3. DWSI of rat brain using (a) DW-EPSI and (b) DW-LSEPSI. The left images show NAA maps and the right graphs show average spectra in the red rectangles in the left images. Yellow lines in the left images show edges of a rat head. (c) ADC map of NAA using DW-LSEPSI. Color represents ADC value. Fig. 1. Sequence diagram of DW-LSEPSI. Diffusion-weighted Line-scan Echo-planar Spectroscopic Imag...

The prognostic value of the primary lesion pretreatment apparent diffusion coefficient (ADC), which is obtained by diffusion-weighted magnetic resonance imaging (MR-DWI), remains unknown in nasopharyngeal carcinoma (NPC). Thus, to investigate whether the pretreatment ADC value as measured from the primary site on MR-DWI is an independent prognostic factor in NPC, we retrospectively reviewed a c...

Fig 3. An example of a coregistered ADC map and [F]FLT image from the center slice of a tumor (T), which both demonstrate distinct regions of heterogeneity. These preliminary coregistration studies suggest that there may be an inverse correlation between [F]FLT uptake and ADC values, particularly in highly heterogeneous tumor regions. Ongoing work is aimed at unraveling and quantifying this rel...