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Background Adenosine, an agonist of the A2a receptor, is widely used for stress CMR. However, target receptors for adenosine are heterogeneous in their location and facilitated physiologic effects. A2b and A3 receptors are responsible for bronchospasm and peripheral arteriolar vasodilation; A1 receptors are responsible for AV block. The rate of adverse reactions with adenosine approaches 80%, c...

Methods Performed stress CMR for 80 patients referred for ischemia assessment after Invasive Coronary angiogram. CMR examination included are Cine Cardiac function , Adenosine stress Perfusion, Rest Perfusion and late Gadolinium enhancement with appropriate sequences. Follow up done for these Patients for a period of one year after CMR study for occurrence of Major adverse cardiac events (MACE ...

BACKGROUND Angina has important implications for patients' quality of life and healthcare utilization. Angina management after acute myocardial infarction (MI) treated with percutaneous coronary intervention (PCI) is unknown. METHODS AND RESULTS TRANSLATE-ACS (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronar...

Methods CE-MARC was a prospective study of 752 patients with suspected angina. All patients were scheduled for CMR, SPECT and X-ray coronary angiography. Multi-parametric CMR comprised adenosine stress/rest perfusion, cine imaging, late gadolinium enhancement and MR coronary angiography. Gated adenosine stress/rest SPECT was performed using 99mTc-tetrofosmin. The primary outcome was the diagnos...

Background Adenosine perfusion cardiac magnetic resonance imaging (CMR) has been proven to be useful for short-term prognosis in patients with stable coronary artery disease. Most of the available studies so far only included specific subsets of patients and defined rather soft clinical endpoints. Thus, it remains still uncertain, whether CMR can be used as prognostic tool concerning long-term ...

OBJECTIVES The aim of this study was to assess whether endogenous accumulation of adenosine, induced by low-dose dipyridamole infusion, protects from exercise-induced ischemia. BACKGROUND Adenosine is a recognized mediator of ischemic preconditioning in experimental settings. METHODS Ten patients (all men: mean age 63.4 +/- 7.3 years) with chronic stable angina, angiographically assessed co...

In 54 patients undergoing elective or emergency aortocoronary bypass grafting, angiographic and electrocardiographic changes were studied. Five patients with unstable angina and fivepatients with evolvingmyocardial infarction were included. .High energy phosphate metabolism and the histologic appearance of the myocardium were analyzed in transmural biopsy specimens acquired at the time of surge...

BACKGROUND Although an angina attack by vasospastic angina (VSA) can usually be relieved or controlled with nitrates and calcium channel blockers (CCBs), there are some patients who cannot be controlled even by higher doses and combinations of these drugs. Cilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular cyclic adenosine monophosphate (cAMP) contents. A st...