there are several reports that adenosine and carbamazepine have pharmacodynamic interaction. i n this study the antinociceptive interaction o f these two agents was evaluated in mice by the hot plate test. agents were injected intraperitoneally. 0.2 and 0.4 mg/kg doses of r-phenylisopropyladenosine (r-pia) substantially showed antinociceptive effects. carbamazepine had antinociceptive actions e...

Epilepsy is among the most common disorders of the central nervous system and there is not an absolute method for its treatment. It has been shown that each seizure has a depressing effect on the following seizure. Thus, finding the mechanisms responsible in this phenomenon can improve our knowledge toward new ways for epilepsy treatment. In this study, the role of adenosine A1 receptors in ...

introduction: considering the anticonvulsant effects of a1 adenosine receptors and the anatomical connections between pjriform cortex and amygdala, in this study, the role of a1 adenosine receptors activity of piriform cortex neurons on amygdala kindled seizures was investigated in rats. material and methods: the rats were fully kindled by daily electrical stimulation of amygdala. n6-cyclohexyl...

In this study the role of adenosine A1 receptors of the CA1 region of hippocampus on piriform cortex–kindled seizures was investigated in rats. Obtained results showed that in kindled animals, bilateral microinjection of N6–cyclohexyladenosine (CHA), an adenosine A1 receptor agonist, at doses of 10 and 100 mM into the hippocampal CA1 region decreased the afterdischarge duration (ADD), stage 5 s...

In this study the role of adenosine A1 receptors of the CA1 region of hippocampus on piriform cortex–kindled seizures was investigated in rats. Obtained results showed that in kindled animals, bilateral microinjection of N6–cyclohexyladenosine (CHA), an adenosine A1 receptor agonist, at doses of 10 and 100 mM into the hippocampal CA1 region decreased the afterdischarge duration (ADD), stage 5 s...

introduction: activity of the paragigantocellularis (pgi) nucleus located in the rostral ventrolateral medulla is the mediator of dependence, tolerance and withdrawal syndrome. the most important systems which change their activity during morphine consumption include glutaminergic, opioidergicand purinergic (especially adenosine) receptors in the pgi nucleus. however, it has been shown that the...

It is well known that the metabolic factors play an important role in the regulation of angiogenesis. Increased metabolic activity leads to decreased oxygen levels and causes tissue hypoxia. Hypoxia starts different signals to stimulate angiogenesis and promotes oxygen delivery to tissues. It has been suggested that released adenosine from hypoxic tissues plays a vital role in angiogenesis. ...

Adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, Alzheimer’s disease, Parkinson’s disease and schizophrenia. Adenosine receptors have been detected: A1R, A2AR (A2AR), A2BR, and A3R. A1R and A2R inhibit cAMP production, while A2AR and A2BR stimulate cAMP product...

Objective: Cinnamaldehyde may be responsible for some health benefits of cinnamon such as its neuroprotective effects. We aimed to investigate the cinnamaldehyde neuroprotective effects against amyloid beta (Aβ) in neuronal SHSY5Y cells and evaluate the contribution of N-methyl-D-aspartate (NMDA), ryanodine, and adenosine receptors and glycogen ...

objective: it has been suggested that low frequency stimulation (lfs) exerts its inhibitory effect on epileptogenesis through adenosine receptors activation. in the present study, effect of different lfs frequencies on a1 and a2a receptors gene expression was investigated in perforant path kindled seizures. materials and methods: animals were kindled by perforant path stimulation. afterdischarg...