Objective: Stress plays an important role in affecting adrenal gland anatomy and structure which may have connection with suicidal behaviour in depressed patients. The increase in adrenal cortical function is paralleled by increased adrenal weight and zone specific cortical width. Method: Adrenal glands from persons aged 20-85 years who died unexpectedly either from road traffic accident or com...

BACKGROUND Adrenocortical tumors comprise frequent adenomas (ACA) and rare carcinomas (ACC). Human cytochrome P450 2W1 (CYP2W1) is highly expressed in some cancers holding the potential to activate certain drugs into tumor cytotoxins. OBJECTIVE To investigate the CYP2W1 expression in adrenal samples and its relationship with clinical outcome in ACC. MATERIAL AND METHODS CYP2W1 expression wa...

Mitochondrial dynamics plays a significant role in shaping the mitochondrial network and maintaining function. Imbalanced can cause dysfunction leading to wide range of diseases/disorders. The aim this study was investigate expression markers regulatory molecules whole adrenal glands, cortices, medullae obtained from adult male rats exposed acute repeated psychophysical stress, most common stre...

Adrenal hormones, ACTH plasma concentrations and the ultrasonographic evaluation of adrenal glands are considered complementary in clinical evaluations hypothalamic–pituitary–adrenal (HPA) axis function several species. In dogs, age, size weight have a significant effect on glands. neonatal foals, measurements been demonstrated to be reliable; however, individual variables features has not inve...

Considering the physiological importance and need of greater morphophysiological knowledge of adrenal glands, the aims of present study were compare the morphometric data between left and right adrenal of male and female; perform a histological, scanning and transmission electron microscopy study showing tissue constitution of glands; finally, in order to define the presence and correct site of...

Very few cases of pheochromocytoma in functional accessory adrenal glands have been documented in literature. We present a twenty-four year old Nigerian female who presented with pheochromocytoma. Investigations revealed a suprarenal mass, which was diagnosed as an accessory gland adrenal tumour at surgery. This shows that accessory adrenal glands can be a basis for development of pheochromocyt...

The synthetic oestrogen diethylstilbestrol (DES), which is known to bind oestrogen receptors (ERs), has been reported to have adverse effects on endocrine homeostasis; however, the molecular mechanisms underlying these effects are poorly understood. In this study, we treated rats with DES and found high levels of this compound in the liver, adrenal glands and pituitary gland, as compared with o...

Observation of the changes in the occurrence and distribution of nucleotide (P2X) receptors in the adrenal gland during development and ageing, and correlation with the changes in adrenal status at similar stages may give morphological insights into the functions of purine nucleotides in the gland. Age-related changes in the localization of all seven subtypes of the P2X receptor in the adrenal ...

We report a case of non-familial juvenile primary aldosteronism (PA). Super-selective adrenal venous sampling identified less aldosterone production in the right inferior adrenal segment than others. Bilateral adrenalectomy sparing the segment normalized blood pressure and improved PA. Both adrenals had similar histologies, consisting of a normal adrenal cortex and aldosterone synthase-positive...