OBJECTIVE To determine if central corneal thickness (CCT) is related to the level of glaucoma severity at the initial examination. METHODS The initial visit to a glaucoma specialist by consecutive patients with primary open-angle glaucoma from 1997 to 2002 was reviewed retrospectively. Each patient's age, sex, race, family history of glaucoma, number of glaucoma medications, visual acuity, sp...

PURPOSE The pathophysiological events that occur in advanced glaucoma are not well characterized. The principal purpose of this study is to characterize the gene expression changes that occur in advanced glaucoma. METHODS Retinal RNA was obtained from canine eyes with advanced glaucoma as well as from healthy eyes. Global gene expression patterns were determined using oligonucleotide microarr...

Over the last half century, open-angle glaucoma management has revolved mainly around topical medical treatment with or without laser trabeculoplasty, with gold standard trabeculectomy kept back for patients with advanced and progressing glaucoma. Keeping in mind the possible complications associated with trabeculectomy and glaucoma valves,1 these are usually kept for late glaucoma treatment al...

To evaluate the efficacy and safety of CO2 laser-assisted sclerectomy surgery (CLASS) in Chinese patients with advanced glaucoma.Patients with advanced glaucoma who were candidates for glaucoma filtration surgery were included. The intraocular pressure (IOP) and number of antiglaucoma medications were documented before surgery and at all postoperative clinic visits. All intra- and postoperative...

Primary angle closure glaucoma is one of the leading causes of blindness in Asia. Surgical intervention is often needed to control the intraocular pressure for patients with advanced glaucoma. The current surgical modalities include laser peripheral iridoplasty, lens extraction, trabeculectomy, goniosynechialysis, combined procedures, glaucoma implants, and cyclodestruction. The choice of surgi...

PURPOSE To compare moderate and advanced glaucoma patients in Ghana. METHODS A retrospective cross-sectional study of 164 patients with primary open-angle glaucoma (POAG) were separated into moderate and advanced glaucoma groups. Definitions of moderate and advanced POAG were derived from International Geographical and Epidemiologic Ophthalmology criteria and included clinical assessment of o...

Primary angle closure glaucoma is usually a bilateral disease, though it may be asymmetrical. However, it is unusual to see advanced glaucoma in one eye and no disk damage in the other. We present a case of unilateral angle closure glaucoma complicated by an optic disk pit and iridociliary cysts. How to cite this article: Kaushik S, Ichhpujani P, Kaur S, Pandav SS. Optic Disk Pit and Iridocilia...

OBJECTIVE To compare the glaucoma diagnostic capabilities offered by Stratus and Cirrus spectral-domain optical coherence tomography (OCT). METHODS One hundred subjects with glaucoma and 74 healthy subjects were tested by Stratus and Cirrus OCT. Areas under the receiver operating characteristic curves (AUCs) of average, 4-quadrant, and 12-sector retinal nerve fiber layer thicknesses and sensi...

PURPOSE To investigate the serum levels of Brain Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in patients affected by primary open angle glaucoma with a wide spectrum of disease severity compared to healthy controls and to explore their relationship with morphological and functional glaucoma parameters. MATERIALS AND METHODS 45 patients affected by glaucoma at different st...

Iris neovascularization (NVI) in eyes with newly diagnosed retinoblastoma is a hallmark of advanced tumor. These eyes often display secondary glaucoma and additional partial or complete retinal detachment. From a clinical perspective, NVI with secondary glaucoma is noted in approximately 12% of eyes with retinoblastoma, and from a pathology perspective, NVI has been found in 44% of eyes followi...