Cutaneous drug reactions are the most frequently occurring adverse reactions to drugs. Among hospitalized patients, the incidence of these reactions ranges from 1 to 3%. The frequency of cutaneous reactions to specific drugs may exceed 10%. These reactions may range from mildly discomforting to those that are life-threatening. Anti-infective and anticonvulsant agents are among the drugs most co...

conclusions pain management in patients with liver dysfunction is always challenging to physicians because of the adverse reactions of drugs, especially opioids. opioids should be used cautiously since they can cause sedation, constipation and sudden encephalopathy effects. since the clearance of these drugs in patients with hepatic insufficiency is decreased, the initial dose must be decreased...

Adverse cutaneous reactions to psychoactive drugs are common. They disturb and interrupt therapy often leading to non-compliance. The majority of adverse cutaneous reactions are benign if they are promptly recognized. Withdrawal of suspected drug is the first step for consequent treatment. As some adverse cutaneous reactions are life threatening, the most important action is to discontinue the ...

BACKGROUND Previous studies have shown that calcium channel blockers can cause cutaneous adverse reactions; however, the amounts of data collected are limited. Recently, there have been new drugs available for which only a few reports have been published with regard to cutaneous adverse reactions. OBJECTIVE The purpose of our study was to estimate the rate and to study clinical patterns of cu...

BACKGROUND The aim of this study was to analyze the clinical characteristics of patients with adverse cutaneous drug reactions, which occur when a medicinal product results in cutaneous morbidity. METHODS The study included 308 patients who were diagnosed as having an adverse cutaneous drug reaction during the study period (2007-2009). In 84 cases, histopathologic examination of skin biopsies...

Cutaneous adverse reactions are reported for many therapeutic agents and, in general, are observed in between 0% and 8% of treated patients depending on the drug. Antiosteoporotic agents are considered to be safe in terms of cutaneous effects, however there have been a number of case reports of cutaneous adverse reactions which warrant consideration. This was the subject of a working group meet...

Cutaneous eruptions are a commonly reported adverse drug reaction. Cutaneous adverse drug reactions in the pediatric population have a significant impact on patients' current and future care options. A patient's recollection of having a "rash" when they took a medication as a child is a frequent reason for not prescribing a particular treatment. The quick detection and treatment of cutaneous ad...