Previous papers in this series have reported the hypoxanthinedependent oxidation of sulfite by cyanide-inhibited xanthine oxidase (1) and experiments which permitted postulation of the structure of the active site of this enzyme (2). In the present study, xanthine oxidase acting on its substrates has been found to initiate the aerobic oxidation of sulfite by free radical chains of great length ...

Metabolic interventions improve performance during demand-induced ischemia by reducing myocardial lactate production and improving regional systolic function. We tested the hypotheses that 1) stimulation of glycolysis would increase lactate production and improve ventricular wall motion, and 2) the addition of fatty acid oxidation inhibition would reduce lactate production and further improve c...

Cooperative catalysis between Cu(II) and redox-active organic cocatalysts is a key feature of important chemical and enzymatic aerobic oxidation reactions, such as alcohol oxidation mediated by Cu/TEMPO and galactose oxidase. Nearly 20 years ago, Markó and co-workers reported that azodicarboxylates, such as di-tert-butyl azodicarboxylate (DBAD), are effective redox-active cocatalysts in Cu-cata...

an efficient synthetic method for successful synthesis of amine denderon on sba-15 and related pd (ii) complex has been developed. this modified mesoporous material was characterized by various techniques such as tem, xrd, atomic absorption spectroscopy, n2 adsorption-desorption, and ft-ir. the catalytic activities of the prepared catalysts were investigated by employing aerobic oxidation of al...

An efficient catalytic method has been developed for aerobic oxidation of primary amines to the corresponding nitriles. The reactions proceed at room temperature and employ a catalyst consisting of (4,4'- t Bu2bpy)CuI/ABNO (ABNO = 9-azabicyclo[3.3.1]nonan-3-one N-oxyl). The reactions exhibit excellent functional group compatibility and substrate scope, and are effective with benzylic, allylic a...

1. The acute hepatotoxic action of dimethylnitrosamine was investigated with homogenates and mitochondrial preparations from the livers of rats injected with 100 mg./kg. body weight at various times between 8 and 24 hr. before killing. 2. Aerobic oxidation of pyruvate, octanoate, L-malate, citrate, L-glutamate, a-oxoglutarate and ,-hydroxybutyrate progressively decreased after the twelfth hour ...

Nanodroplets of sulfur-stabilised copper nanoparticles effectively catalyse the aerobic oxidation amines to imines under ambient conditions.

The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids in extremely high yields. The reaction conditions are very mild and greener, re...