Background: Nucleolar organizer regions (NORs) are defined as nucleolar components containing a set of argyrophilic proteins, which are selectively stained by silver methods. After silver-staining, the NORs can be easily identified as black dots exclusively localized throughout the nucleolar area and are called AgNORs. AgNORs have been used to assess biologic aggressiveness of lesions, such as ...

In order to assess the prognostic significance of silver-stained nucleolar organizer region (AgNOR) proteins, a standardised analysis has been performed on 34 ocular globes with choroidal melanomas. On formalin-fixed paraffin-embedded sections, the visualisation and quantification of AgNORs were achieved according to the guidelines of the Committee on AgNOR Quantification (1995); statistical an...

Argyrophilic nucleolar organizer region (AgNOR) counts in cytologic and histologic lymph node samples from healthy dogs and dogs with lymphoma were compared. Control samples were taken from 10 Beagle dogs (six female and four male dogs, 1.5-2 years), and lymphoma samples were taken from 16 dogs. Cytologic samples were obtained by fine-needle aspiration and impression and histologic samples by e...

Settings. Despite the limited diagnostic utility of AgNORs (argyrophilic nucleolar organiser region-associated proteins) for individual breast lesions, AgNOR analysis bears a significant potential for characterizing cell proliferative activity of breast lesions. Methodology. The present study investigated the relationship between mean AgNORs count and immunohistochemical expression of ER, PR, H...

Objectives: Assessment of the cell proliferation rate in tissues can be one of the markers for impending malignancy in precancers. The state of activation and the proliferation activity of the cells can be assessed by the frequency of silver stained Nucleolar Organiser regions (AgNOR) within the nuclei which is significantly higher in malignant cells. The present study was carried out to analyz...

Background: Nucleolar organizing regions (NORs) are associated with proliferative activity and represents as a diagnostic aid in several neoplastic entities. Objective: The purpose of this study was to determine and compare the AgNOR (Silver binding nucleolar organizing region) count in healthy oral mucosa, oral leukoplakia and oral squamous cell carcinoma (OSCC). Methods: The biopsied tissue s...

After the pioneering work by Ploton et al. [1] silver staining of nucleolar organizer regions (AgNOR) has been introduced into tumour pathology as a proliferation marker which is closely related to the rapidity of cell cycle [2]. Owing to wet autoclave pretreatment introduced by Öfner et al. [3] AgNOR analysis has now widely been standardized in tissue sections [4]. In cytological specimens, ho...

PURPOSE We have previously demonstrated that the AgNOR count in proliferating cells is a predictor of tumor recurrence in superficial bladder tumor (J. Urol. 162 (1999), 63-68). In the present study, we evaluate the type of AgNOR associated with cell cycles as a prognostic factor in invasive bladder tumor using a double staining technique employing both AgNOR and MIB-1 labelling. MATERIALS AN...

OBJECTIVES To evaluate the correlation of AgNOR count and colposcopy in cases of suspicious cervix. METHODS A hundred women presenting in OPD with complaints of postcoital bleeding, discharge per vaginum, pain in the lower abdomen, or intermenstrual bleeding were subjected to colposcopy. After colposcopy, a cervical biopsy was done. Routine paraffin sectioning was done for these biopsy specim...