Polarized growth in pollen tubes results from exocytosis at the tip and is associated with conspicuous polarization of Ca(2+), H(+), K(+), and Cl(-) -fluxes. Here, we show that cell polarity in Nicotiana tabacum pollen is associated with the exclusion of a novel pollen-specific H(+)-ATPase, Nt AHA, from the growing apex. Nt AHA colocalizes with extracellular H(+) effluxes, which revert to influ...

Acquired hemophilia A (AHA) is a rare hemorrhagic disease in which autoantibodies against coagulation factor VIII- (FVIII-) neutralizing antibodies (inhibitors) impair the intrinsic coagulation system. As the inhibitors developed in AHA are autoantibodies, the disease may have an autoimmune cause and is often associated with autoimmune disease. Although acute hemorrhage associated with AHA may ...

Recent reports from the American Heart Association (AHA) and by lead authors of the 2014 AHA guidelines for cardiovascular screening in athletes present many inconsistencies that need to be critically examined. In three different AHA statements (1996, 2007, 2014), the AHA has endorsed cardiovascular screening: “Both AHA and ESC consensus panels have agreed previously that screening to detect ca...

BACKGROUND Retinoids (RC), alpha-hydroxy acids (AHA), and salicylic acid (BHA) treat acne through differing mechanisms of action. It is theorized that optimal improvement can be achieved by combining the RC-induced normalization of cellular differentiation, AHA-induced exfoliation in hydrophilic areas, and BHA-induced exfoliation in lipophilic areas. AHA and RC have been combined in a bioengine...

Fifty-two cases of autoimmune hemolytic anemia (AHA) were observed within a series of 1203 patients (4.3%) with chronic lymphocytic leukemia (CLL) followed at a single institution. Nineteen were observed at the time of CLL diagnosis and 33 during the clinical follow-up. Ninety percent of the patients with CLL/AHA showed active CLL and 25% had been treated previously. The antierythrocyte autoant...

Modeling potential evapotranspiration (ET0) is an important issue for water resources planning and management projects involving droughts flood hazards. Evapotranspiration, one of the main components hydrological cycle, highly effective in drought monitoring. This study investigates efficiency two machine-learning methods, random vector functional link (RVFL) relevance machine (RVM), improved w...