2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP/ARTD14) is a member of the PARP family and is regulated by the aryl hydrocarbon receptor (AHR); however, little is known about TiPARP function. In this study, we examined the catalytic function of TiPARP and determined its role in AHR transactivation. We observed that TiPARP exhibited auto-mono-ADP-ribosylt...

The pBEVY (bi-directional expression vectors for yeast) plasmids were designed with constitutive and galactose-induced bi-directional promoters to direct the expression of multiple proteins in Saccharomyces cerevisiae . Using human estrogen receptor as a test gene, relatively balanced expression levels from each side of a bi-directional promoter were observed. Expression of a functional heterod...

Running title: Cuartero et al.; L-Kyn/AhR mediate damage after stroke Address for r r Co Co Corr rr rres es spo po p nd nd n en en enc c ce: Abstract Background—AhR (Aryl hydrocarbon receptor) is a transcription factor that belongs to the basic

Abstract Th17-cells play a key role in the pathogenesis of autoimmune hepatitis (AIH), severe hepatopathy characterized by hypergammaglobulinemia, seropositivity for autoantibodies and interface on histology. Aberrant Th17-cell response AIH is linked to alterations aryl-hydrocarbon-receptor (AHR) signaling. These result inability respond AHR activation. Since can be regulated upon binding aryl-...

The aryl hydrocarbon receptor (AHR) is a transcription factor which activates gene transcription by binding to its corresponding enhancer as the heterodimer, which is consisted of AHR and the aryl hydrocarbon receptor nuclear translocator (ARNT). Human AHR can be rather difficult to study, when compared among the AHR of other species, since it is relatively unstable and less sensitive to some l...

Resveratrol, a compound present in a variety of plants, was recently shown to have potent chemopreventive activity against aryl hydrocarbon-induced tumorigenesis in mice. Therefore, in the present study, we examined the effect of resveratrol on the function of the aryl hydrocarbon receptor (AHR) and the transcription of CYP1A1 in human HepG2 hepatoma cells. Resveratrol inhibited the increase in...

Metadichol ® a novel nano emulsion of lipid alcohols is an Inverse agonist of Vitamin D Receptor (VDR). In this communication, we show that Metadichol is an inverse agonist of the nuclear receptor AHR (Aryl Hydrocarbon receptor) and also an inhibitor of NRF2 (Nuclear factor (erythroid-derived 2)-like 2) and is a transcription factor that is ubiquitously expressed at low levels in all human orga...

Metadichol ® a novel nano emulsion of lipid alcohols is an Inverse agonist of Vitamin D Receptor (VDR). In this communication, we show that Metadichol is an inverse agonist of the nuclear receptor AHR (Aryl Hydrocarbon receptor) and also an inhibitor of NRF2 (Nuclear factor (erythroid-derived 2)-like 2) and is a transcription factor that is ubiquitously expressed at low levels in all human orga...

The aryl hydrocarbon receptor (AhR) regulates expression of genes encoding drug/xenobiotic metabolizing enzymes. Cytochrome P450 (CYP) 3A5 is involved in drug metabolism. However, regulation CYP3A5 gene not yet well understood. In this study, we aimed to investigate the effect ligands AhR on expression. mRNA was induced by polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (3M...