Chronic stable asthma is characterized by inflammation of the airway wall, with abnormal accumulation of basophils, eosinophils, lymphocytes, mast cells, macrophages, dendritic cells, and myofibroblasts. Airway inflammation is not limited to severe asthma, but is also found in mild and moderate asthma. This inflammation results in a peculiar type of lymphocytic infiltration whereby Th2 lymphocy...

Asthma is a clinical entity characterised by a combination of three features: airway obstruction with spontaneous and/or pharmacological reversibility, increased airway responsiveness (BHR), and airway inflammation. 2 Asthma originates with airway inflammation which results in the pathological process and ultimately culminates in symptoms. Airway inflammation has been considered the primary eve...

Asthma is a clinical entity characterised by a combination of three features: airway obstruction with spontaneous and/or pharmacological reversibility, increased airway responsiveness (BHR), and airway inflammation. 2 Asthma originates with airway inflammation which results in the pathological process and ultimately culminates in symptoms. Airway inflammation has been considered the primary eve...

PURPOSE Cockroach (CR) is an important inhalant allergen and can induce allergic asthma. However, the mechanism by which CR induces airway allergic inflammation and the role of endotoxin in CR extract are not clearly understood in regards to the development of airway inflammation. In this study, we evaluated whether endotoxin is essential to the development of CR induced airway allergic inflamm...

in traditional chinese medicine, arsenous compounds, including arsenic trioxide (ato), are often used to treat many diseases, which are safe and effective. recently, studies have indicated that th17– il-17 involved in the pathogenesis and development of asthma. the goal of this study was to investigate the effect and mechanism of ato on asthma, especially the th17– il-17 axis. we used oval bumi...

inadequate attention given to the management of asthma and ways of improving treatment could be a significant factor for the increase morbidity and mortality from asthma despite major advances in our understanding of the pathophysiology of the disease. there seems to be paucity of data concerning the management pattern and burden of asthma in africa. this study was undertaken to determine the p...