introdouction: the aim of this study was to compare information regarding pharyngeal airway sizes in adolescent subjects with different malocclusion classes obtained from lateral cephalograms and 3–dimensional (3d) cone-beam computed tomography (cbct) scans. materials and methods: in this prospective cross-sectional study, cbct scans and lateral cephalograms of 35 subjects, taken within one wee...

Immature rabbits have greater maximal airway narrowing and greater maximal fold increases in airway resistance during bronchoconstriction than mature animals. We have previously demonstrated that excised immature rabbit lungs have more distensible airways, a lower shear modulus, and structural differences in the relative composition and thickness of anatomically similar airways. In the present ...

The purpose of the present study was to evaluate the accuracy and reliability of airway volume digital measurements of cone-beam computed tomography (CBCT) compared with the manual measurements of an airway model. An acrylic airway model was constructed and attached to a human dry skull in the natural position of the airway passage. The total and internal airway volumes, as well as the most con...

UNLABELLED L-selectin is a cell adhesion molecule, which mediates leukocyte rolling on bronchopulmonary endothelium. Previous studies in a murine model of allergic airways disease have shown that L-selectin plays a role in the regulation of airway hyperresponsiveness in asthma via mechanisms independent of inflammation. Airway remodeling has been shown to modulate airway hyperresponsiveness ind...

A theoretical model is presented describing the reopening by an advancing air bubble of an initially liquid-filled collapsed airway lined with deformable epithelial cells. The model integrates descriptions of flow-structure interaction (accounting for nonlinear deformation of the airway wall and viscous resistance of the airway liquid flow), surfactant transport around the bubble tip (incorpora...

BACKGROUND Asthma is a chronic disease that is characterized by airway hyperresponsiveness and airway remodeling. The underlying mechanisms that mediate the pathological processes are not fully understood. Abl is a non-receptor protein tyrosine kinase that has a role in the regulation of smooth muscle contraction and smooth muscle cell proliferation in vitro. The role of Abl in airway hyperresp...

Monitoring variations in the upper airway narrowing during sleep is invasive and expensive. Since snoring sounds are generated by air turbulence and vibrations of the upper airway due to its narrowing; snoring sounds may be used as a non-invasive technique to assess upper airway narrowing. Our goal was to develop a subject-specific acoustic model of the upper airway to investigate the impacts o...