INHIBITION OF ALANINE AMINOTRANSFERASE (ALAT) IN SILICO AND IN VIVO PROMOTES MITOCHONDRIAL METABOLISM TO IMPAIR MALIGNANT GROWTH* Gregor Beuster*, Kim Zarse*, Christoph Kaleta†, René Thierbach‡, Michael Kiehntopf§, Pablo Steinberg‡, Stefan Schuster†, Michael Ristow* װ 2 * Dept. of Human Nutrition, Inst. of Nutrition, University of Jena, Jena, D-07743, Germany, † Dept. of Bioinformatics, School ...

The effect of cobalt on the total proteins, protease activity, free amino acids, alanine amino transferase (ALAT) activity and aspartate amino transferase (AAT) activity were studied. The increase of total protein content in silk gland may be either due to increased efflux or decreased proteolysis activity which might lead to accumulation of protein content. The decrease of protease activity le...

Miokarditis merupakan suatu penyakit inflamasi miokard dengan presentasi klinis dan onset yang bervariasi. Kesulitan dalam diagnosis seringkali menyebabkan pasien yang datang dalam kondisi akut tidak terdiagnosis sebagai miokarditis, lalu mendapatkan penanganan yang tidak tepat. Hal ini akan membahayakan karena menyebabkan cedera miokard lebih parah, bahkan dapat menyebabkan kematian mendadak. ...

Aphanamixis polystachya is a traditional medicinal plant of the Meliaceae family in India. A crude ethanolic extract of the leaf of this plant shows a beneficial effect on toxic liver injury. Its antihepatotoxic activity was evaluated on carbon tetrachloride (CCl4)-induced liver injury in a rat model. The assessment of hepatoprotective activity was evaluated by measuring the activities of aspar...

High-dose chloroquine therapy for porphyria cutanea tarda is rarely used now because of its hepatic side-effects. The mechanisms of the effects and side-effects are poorly understood. We describe here effects, side-effects and long-term follow-up in 57 patients with a first-time diagnosis of porphyria cutanea tarda treated with 1-3 phlebotomies followed by 250 mg chloroquine phosphate daily for...

freshwater fish cirrhinus mrigala were exposed to lethal concentration (5 mg/l) for 1,2,3,4 days and sublethal concentration (1 mg/l) for 1,7,14,21 days of cypermethrin to examine the enzymes activity, in functionally three different tissues namely, gill, liver and muscle. activities of aspartate aminotransferase (aat), alanine aminotransferase (alat) and glutamate dehydrogenase (gdh) increased...

OBJECTIVES To establish the level of observer variation for the current ATS/ERS/JRS/ALAT criteria for a diagnosis of usual interstitial pneumonia (UIP) on CT among a large group of thoracic radiologists of varying levels of experience. MATERIALS AND METHODS 112 observers (96 of whom were thoracic radiologists) categorised CTs of 150 consecutive patients with fibrotic lung disease using the AT...

The objective of this research was to identify maternal and fetal characteristics as prognostic markers of congenital cytomegalovirus (CMV) infection. This is a descriptive study of 13 cases of congenital CMV infection referred to Institute de Puericulture et Perinatologie de Paris (IPP) from January 2005 to October 2006. Amniotic fluid puncture was performed to research CMV polimerase chain re...

Male Wistar rats were given tamoxifen (2 or 4 mg/kg bw/day) and sodium fluoride (20 mg/kg bw/day), five days a week, for six months. Significant adverse changes were observed in the activities of the serum enzymes alanine and aspartate aminotransferase (AlAT and AspAT) and gammaglutamyl transpeptidase (γ-GT), the liver content of cytochrome P-450, and the activity of hepatic NADPH-cytochrome c ...