BACKGROUND & OBJECTIVES Aluminum (Al) toxicity is closely linked to the pathogenesis of Alzheimer's disease (AD). This experimental study was aimed to investigate the active avoidance behaviour of rats after intrahippocampal injection of Al, and biochemical and immunohistochemical changes in three bilateral brain structures namely, forebrain cortex (FBCx), hippocampus and basal forebrain (BF). ...

Problem statement: Aluminum (Al) is an indifferent element from a toxicological point of view. In recent years, however, Al has been implicated in the pathogenesis of several clinical disorders. One of the most frequently described problem in aluminum toxicity is anemia. The present study was carried out to determine the effectiveness of Camel’s milk in alleviating the toxicity of aluminum chlo...

The reaction of 8-(trimethylsiloxy)quinoline (QOTMS) with BCl3 and (aryl)BCl2 forms QOBCl2 and QOBCl(aryl). The subsequent addition of stoichiometric AlCl3 follows one of two paths, dependent on the steric demands of the QO ligand and the electrophilicity of the resulting borenium cation. The phenyl- and 5-hexylthienylborenium cations, QOBPh(+) and QOBTh(+), are formed, whereas QOBCl(+) is not....

We use ab initio molecular dynamics simulations based on density-functional theory and quantum-chemistry calculations on molecular clusters to examine the structure of liquid AlCl3. In the past, conflicting descriptions of the short-range-order in molten AlCl3, based on either edge-sharing dimers or corner-sharing oligomers, have been proposed. This liquid also poses a simulation challenge, due...

A worker with occupational exposure to aluminum powder developed asthmatic symptoms three years and six months after starting work. Skin tests (prick and intradermal) to aluminum chloride (AlCl3) were negative. Inhalation challenge test with 10 mg of aluminum powder and 10 mg/ml of AlCl3 solution induced an early asthmatic response. Sodium cromoglycate pre-treatment reduced AlCl3-induced bronch...

The effects of different concentrations of CdCl2 and AlCl3 on NH4+ and NO2? oxidation in an aqueous system were investigated. AlCl3 had no effect on NH4+ removal and its oxidation to NO2?, whereas NO2? disappearance was greatly enhanced by AlCl3. In contrast, CdCl2 delayed removal of NH4+ and its subsequent oxidation to NO2? and also decreased the rate of NO2? disappearance. When compared to th...

This is the first study to systematically investigate the different behaviors of Microcystis aeruginosa in the sludges formed by AlCl3, FeCl3, and polymeric aluminium ferric chloride (PAFC) coagulants during storage. Results show that the viability of Microcystis aeruginosa in PAFC sludge was stronger than that of cells in either AlCl3 or FeCl3 sludge after the same storage time, while the cell...

Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized by progressive loss of cognitive functions and memory. Excessive intake of aluminum chloride in drinking water is associated with amyloid plaques and neurofibrillary tangles in the brain, which are the hallmark of AD. We have evaluated brain energy metabolism in aluminum chloride (AlCl3) mouse model of AD. In a...

Aluminum is known to exert neurotoxic effects associated with various neurodegenerative disorders, including Alzheimer's disease (AD). Ibuprofen is a well-known non-steroidal anti-inflammatory drug, which has demonstrated potential efficacy in the treatment of numerous inflammatory and neurodegenerative disorders, including AD. The present study aimed to investigate the protective effects of ib...

The present study was aimed at determining the effectiveness of nitric oxide synthase (NOS) inhibitors: N-nitro-L-arginine methyl ester, 7-nitroindazole and aminoguanidine in modulating the toxicity of AlCl3 on superoxide production and the malondialdehyde concentration of Wistar rats. The animals were sacrificed 10 min and 3 days after the treatment and the forebrain cortex was removed. The re...