objective(s): oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. licochalcone b, an extract of licorice root, has shown antioxidative properties. this study was to investigate the effects and mechanisms of licochalcone b in ethanol-induced hepatic injury in an in vitro study. materials and methods: an in vitro model of ethanol-induced cytotoxicity in brl cel...

objective: neurocognitive deficits are now recognized as part of the fundamental disturbances and are a major determinant of functional outcome in psychosis. a cross-sectional association between cognitive deficits and poor social and occupational outcomes has been demonstrated; and treatment of cognitive impairment at the time of the first episode may have the potential to change functional ou...

The combination of alcohol with an energy drink (ED) is believed to contribute to risky alcohol-drinking behaviors, such as binge drinking. However, the long-term effects on cognition and reward function that are caused by the repeated binge-like ingestion of alcohol and EDs are still poorly known. The present study examined the effects of a history of repeated exposure to alcohol and/or an ED ...

background no study from india has examined pathways to care in alcohol using population systematically. objectives the present study aimed to understand the pathways to care among alcohol-dependent individuals seeking help at a tertiary care center. patients and methods it was a cross-sectional, observational study. a total of 58 subjects diagnosed with alcohol- dependence syndrome as per dsm-...

AIMS To test the hypothesis that the association previously reported between moderate alcohol use and better cognition is an artefact of confounding by (a) higher premorbid education and socioeconomic status; (b) a lifestyle of moderation (using smoking as a risk marker); and (c) decreased alcohol consumption in people with physical illnesses. METHOD Data were analysed from people aged 60-74 ...

Objective(s): Oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. Licochalcone B, an extract of licorice root, has shown antioxidative properties. This study was to investigate the effects and mechanisms of licochalcone B in ethanol-induced hepatic injury in an in vitro study. Materials and Methods: An in vitro model of Ethanol-induced cytotoxicity in BRL cel...

background tramadol is an opioid analgesic indicated for the treatment of moderate and severe pains. in the case of long administration, tramadol has a potential to cause dependency, tolerance and drug abuse. objectives this study aimed to investigate the prevalence and factors associated with tramadol abuse among college students based on the theory of planned behavior (tpb) as a theoretical f...

Redox sensitive transcription factors nuclear factor kappaB (NF-kappaB) and activator protein-1 are involved in the pathogenesis of alcohol-induced disorders. Because of its antioxidative properties, vitamin E may help prevent oxidative stress-induced disorders. The aim of the present study was to delineate the molecular mechanisms associated with alcohol-induced oxidative stress and to see whe...

background: alcohol is a potent teratogen and alcohol use in pregnancy and the periconception period can cause many complications in mother, fetus and neonate.  discussion: alcohol in the mother's blood passes through the placenta to the baby through the umbilical cord. drinking alcohol during pregnancy can cause miscarriage, stillbirth, and a range of lifelong disorders. alcohol-related birth ...