نتایج جستجو برای: alcoholic steatohepatitis
تعداد نتایج: 38571 فیلتر نتایج به سال:
Non-alcoholic fatty liver disease (NAFLD) is a slowly progressive chronic disease, with a high prevalence among obese, dyslipidemic or diabetic people, commonly presented as an asymptomatic mild elevation of serum aminotransferases. We report a patient who experienced an acute form of non-alcoholic steatohepatitis, as the first manifestation of NAFLD, due to exacerbation of pre-existing metabol...
Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) cause significant morbidity and mortality in affected patients and are common causes of liver failure worldwide [1]. NAFLD and ALD are histologically indistinguishable by conventional methods but their disease courses are quite divergent. In particular, ALD patients with steatohepatitis have a more rapid progression to ...
BACKGROUND Pathogenesis and factors for determining progression of alcoholic and non-alcoholic steatosis to steatohepatitis with risk of further progression to liver cirrhosis and cancer are poorly understood. In the present study, we aimed to identify potential molecular signatures for discrimination of steatohepatitis from steatosis. METHODOLOGY AND RESULTS Global microarray gene expression...
BACKGROUND AND AIMS A major impediment to establishing new treatments for non-alcoholic steatohepatitis is the lack of suitable animal models that accurately mimic the biochemical and metabolic characteristics of the disease. The aim of this study was to explore a unique polygenic animal model of metabolic disease as a model of non-alcoholic steatohepatitis by determining the effects of 2% diet...
Methionine and Choline Deficient Diet-induced Non-Alcoholic Steatohepatitis in Rats: Role of MelatoninMohamed M. Amin,Rania F. Ahmed,Dalia O. Saleh
no abstract
â â background a substantial proportion of the mortality in patients with type 2 diabetes mellitus (t2dm) is related to non-alcoholic fatty liver disease (nafld) and its complications. insulin resistance is a major etiologic factor for the development of fatty liver. we aimed to study the prevalence of nafld among t2dm patients and its relation to insulin resistance. methods patients with t2d...
Obesity and metabolic syndrome are healthcare problems that continue to rise in frequency worldwide. Both phenotypes are a strong predictor for development of liver steatosis in the context of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis. Ultrasound may detect steatosis, but its sensitivity is limited and liver biopsy is still considered to be the gold standard. Less invas...
The p66Shc protein controls redox signaling and oxidation-dependent DNA damage in human liver cells.
The p66Shc protein mediates oxidative stress-related injury in multiple tissues. Steatohepatitis is characterized by enhanced oxidative stress-mediated cell damage. The role of p66Shc in redox signaling was investigated in human liver cells and alcoholic steatohepatitis. HepG2 cells with overexpression of wild-type or mutant p66Shc, with Ser36 replacement by Ala, were obtained through infection...
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