BACKGROUND In this work, support vector regression (SVR) was applied to the optimization of extended release from swellable hydrophilic pentoxifylline matrix-tablets and compared to multiple linear regression (MLR). METHODS Binary mixtures comprising ethylcellulose and sodium alginate were used as the matrix-former. The matrix-former : drug weight ratio and the percentage of sodium alginate i...

This review compiles information regarding the use of alginate, and in particular alginate hydrogels, in culturing cells in 3D. Knowledge of alginate chemical structure and functionality are shown to be important parameters in design of alginate-based matrices for cell culture. Gel elasticity as well as hydrogel stability can be impacted by the type of alginate used, its concentration, the choi...

The alginate-based hydrogel was prepared as a pH-sensitive drug delivery system. To enhance the drug loading capacity, activated carbon was introduced as a drug absorbent. The iron oxide was incorporated into the alginate matrix for the magnetic transferring to the target organ. The activated carbon and iron-oxide were dispersed uniformly in the alginate hydrogel. The drug release from the algi...

Intervertebral disc cells cultured in alginate gel are capable of reforming in alginate, a matrix that consists of two compartments: a rim of metabolically active cell-associated matrix and a more abundant, but metabolically less active, further removed matrix. At any one age and in most species, the cell-associated matrix formed by a nucleus pulposus or annulus fibrosus cell cultured in this w...

Assessment of adsorption zinc (II) ions from aqueous solution using alginate-SBA-15 sorbent nanocomposite was investigated as a function of zinc concentration, solution pH, and contact time. For that purpose, the alginate-SBA-15 nanocomposite adsorbent was prepared through encapsulation method by immobilization mesoporous SBA-15 into a polymeric matrix. Identification of functional groups and s...

The ovarian follicle is the functional unit of the ovary that secretes sex hormones and supports oocyte maturation. In vitro follicle techniques provide a tool to model follicle development in order to investigate basic biology, and are further being developed as a technique to preserve fertility in the clinic. Our in vitro culture system employs hydrogels in order to mimic the native ovarian e...

we introduce a new smooth, non-toxic, biocompatible method for cross-linking of gum tragacanth (gt), a polysaccharide of natural origin, in order to serve as a new supporting matrix for immobilization systems.  the modified gum is used as a matrix for the catalysis of the conversion of benzyl penicillin to 6-aminopenicillanic acid (6-apa) by means of escherichia coli atcc11105 with penicillin g...

Wet-spun stimuli-responsive composite fi bers made of covalently crosslinked alginate with a high concentration of single-walled carbon nanotubes (SWCNTs) are electroconductive and sensitive to humidity, pH, and ionic strength, due to pH-tunable water absorbing properties of the covalently crosslinked alginate. The conductivity depends on the material swelling in humid atmosphere and aqueous so...

OBJECTIVE Studies on the biology of the human meniscus cell are scarce. The objective of our studies was to assess survival/proliferation of human meniscus cells in different culture conditions and to characterize the extracellular matrix (ECM) produced by these cells in these artificial environments. The composition of this ECM offers a variable to define the distinct meniscus cell phenotype. ...

Biosorption and biodegradation by microorganisms to remove tributyltin (TBT), a toxic and persistent contaminant, have attracted more and more interests in recent years but information related to microalgae is still inadequate. The present study aims to investigate the removal and degradation of TBT at 10, 50 and 100 mg Sn l 1 contamination levels by alginate-immobilized Chlorella vulgaris bead...