The aim of the present study was to investigate effect antihistamines(Chlorpheneramineand Fexofenadine) on (alkaline phosphatase, aspartate amino transpherase and alanine transferase) in tissue fertilized hens eggs embryos as indicator damage. injection hen's with antihistamines Fexofenadine at 12th day incubation doses (0,5,0,1mg/ egginto air sell)after 24 hour treatment induce significantly d...

It is well known that the individuals with different Mizaj (Temperament) have different morphological features and different psychological profiles. However, very little is known about the variations in their physiological capacities and the variations in their normal values of biochemical substances in the body. In this study, level of enzyme alkaline phosphatase in serum was estimated in 52 h...

Bone-specific alkaline phosphatase (BAP) synthesized by osteoblasts is a highly sensitive and specific marker of the boneforming activity. Paget’s disease is the most common cause of elevated serum BAP. Other causes include osteomalacia, rapid bone loss, bone growth, healing fracture, acromegaly, hyperthyroidism, osteogenic sarcoma, bone metastases, leukemia, myelofibrosis, and rarely myeloma. ...

A test kit (Iso-ALP, Boehringer Mannheim) for measuring human bone alkaline phosphatase activity in serum or plasma was evaluated in five laboratories in three countries. The assay is based on the principle described by Rosalki and Foo (Clin Chem 1984;30:1182-6) and uses wheat germ lectin to precipitate bone alkaline phosphatase. Residual ALP in the supernate in comparison with total ALP is use...

Human placenta alkaline phosphatase (HP-ALP), a glycoprotein, was stained histochemically for the purpose of examining the concanavalin A (Con A) binding sites on the cell surface. HP-ALP was bound to the cell surface by Con A. This simple method successfully detected Con A binding sites on the cell surface.

A cDNA clone for human adult intestinal alkaline phosphatase (ALP) [orthophosphoric-monoester phosphohydrolase (alkaline optimum); EC 3.1.3.1] was isolated from a lambda gt11 expression library. The cDNA insert of this clone is 2513 base pairs in length and contains an open reading frame that encodes a 528-amino acid polypeptide. This deduced polypeptide contains the first 40 amino acids of hum...

The fluctuations in the plasma levels of several bone markers were investigated in newborn calves. Experiment 1 monitored the postnatal changes in the plasma levels of tartrate-resistant acid phosphatase isoform 5b (TRAP5b), total alkaline phosphatase (t-ALP) and bone-specific alkaline phosphatase (BAP) in four calves. These markers increased significantly from 9-20 hr after the first colostrum...

Hepatomegaly is a common finding in primary myelofibrosis (PMF), mostly due to extramedullary hematopoiesis, as demonstrated by liver biopsies in previous studies, and high serum alkaline phosphatase (ALP) is usually the most frequent associated biochemical abnormality. In the current study, we examined the clinical, prognostic and molecular correlates of increased ALP and aspartate aminotransf...

AIMS To consider a possible genetic origin for the persistent unexplained increase in plasma alkaline phosphatase (ALP) in five non-related patients referred over an 18 month period. METHODS Plasma ALP isoenzyme activities were measured in patients and their first degree relatives. RESULTS In each patient there was a noticeable increase in intestinal plasma ALP, either alone or accompanied ...

Gold nanoparticle-conjugated fluorescent hydroxyapatite (AuFHAp) was developed as a smart nanoprobe for measuring alkaline phosphatase (ALP) activity. AuFHAp showed NIR fluorescence due to the hydrolysis of its phosphate groups by ALP. In addition, gold nanoparticles help reduce the nonspecific signal by absorbing nonspecific fluorescence. Through in vitro tests, we confirmed that the AuFHAp pr...