PURPOSE Central and local laboratory concordance for hormone receptor measurement is therapeutically important. This study compares estrogen receptor (ER) and progesterone receptor (PR) measured by local laboratory immunohistochemistry (IHC), central IHC, and central reverse-transcriptase polymerase chain reaction (RT-PCR) using a proprietary 21-gene assay. PATIENTS AND METHODS A case-control...

The protein capsid L1 of the human papilloma virus (HPV) - a key factor in the cervical carcinogenesis - is considered, together with p16, EGFR and COX-2, a characteristic marker for the evaluation of the malignancy progression and prognostic, in terms of tumoral aggressiveness. The purpose of the present study was to make a comparative assessment between the immunohistochemical pattern of p16,...

Objectives: Antigen retrieval (AR) is an important step in Immunohistochemistry (IHC) which used to unmask the antigenic sites and facilitate antigen-antibody binding. Adequate fixation of tissue necessary achieve consistent demonstration antigens that can be masked by chemical process involved formalin processing. Out various methods AR, heat-induced epitope (HIER) have greatly improved qualit...

Dentistry requires development in hand skills throughout the undergraduate and postgraduate programs both in the pre-clinical and clinical settings (Allred, 1977). The level of expertise achieved depends on the level of training, the natural ability of the dentist and also experience. Tooth preparation for a crown is a common procedure in general dental practice and it is essential that dental ...

The goal of preoperative pharmacotherapy in patients with breast cancer is to enable breast conserving surgery in stage T3N0-1M0 or radical mastectomy in patients with primary inoperative tumors (T1-4N0-3M0). The choice of optimal treatment should be based not only on risk factors resulting from the stage but also on predicted cancer responsiveness to the treatment. The breast cancer subtypes d...

BACKGROUND/AIM In light of the controversial published literature, this study aims to examine the potential prognostic role of AR immunohistochemical expression in triple negative breast cancer (TNBC). PATIENTS AND METHODS Ninety patients with TNBC were included in this study; the associations between AR expression (Allred score), clinicopathological variables (stage, grade, histological subt...

Ureaplasma urealyticum and chronic lung disease of prematurity: criticase, however, azithromycin, at the dosage we report, was effective cal appraisal of the literature on causation. Clin Infect Dis 1993;17(suppl against a multidrug-resistant organism with a single 7-day course 1):S112–6. of treatment. If the expensive health outcomes of prematurity and 3. Kundsin RB, Leviton A, Allred EN, Poul...

Interestin fiber reinforced polymeric (FRP) composites for structural highway applications has generated the need for reliable techniques which may be used to measure all of the elastic constants of these materials. Mechanical techniques may only be used to measure some of the engineering constants of these anisotropic materials due to the geometry of the pultruded members. Further, mechanical ...

We are introducing an alternative analytical expression to the electronegativity difference (∆χ) as a function of charge ge, g is factor, fraction electronic devoted bond and e elementary charge, packing factor (p) effective atomic number (Zeff) binary ionic solids, by using very basic Coulomb interaction, modified introduction p, relationship between electric dipole moment (µ) ∆χ in Debye unit...