Hemocyanin sequences allineament shows the presence of highly invariant regions especially in the active site and in the tight intersubunits interaction sites. Comparing the aminoacids in contact regions between monomers is possible to interpret the stability of hexamers.

Prediction of the secondary structure of a protein from its aminoacid sequence remains an important and difficult task. Up to this moment, three generations of Protein Secondary Structure Algorithms have been defined: The first generation is based on statistical information over single aminoacids, the second generation is based on windows of aminoacids –typically 11-21 aminoacids– and the third...

This paper reports about an approach to the classification of proteins’ primary structures taking advantage of the Self Organizing Maps algorithm and of a numerical coding of the aminoacids based upon their physicochemical properties. Hydrophobicity, volume, surface area, hydrophilicity, bulkiness, refractivity and polarity were subjected to a Principal Component Analysis and the first two prin...

A protein is identified by a finite sequence of aminoacids, each of them chosen from a set of 20 elements. The Protein Structure Prediction Problem is the problem of predicting the 3D native conformation of a protein, when its sequence of aminoacids is known. This problem is fundamental for biological and pharmaceutical research. Due to intrinsic computational limits, no general solution is ava...

The use of the solvent engineering has been applied for controlling the resolution of lipase-catalyzed synthesis of β-aminoacids via Michael addition reactions. The strategy consisted of the thermodynamic control of products at equilibrium using the lipase CalB as a catalyst. The enzymatic chemo- and enantioselective synthesis of (R)-(-)-N-benzyl-3-(benzylamino)butanamide is reported, showing t...

Oncogenic kinase Aurora A (AURKA) has been found to be overexpresed in several tumors including colorectal, breast, and hematological cancers. Overexpression of AURKA induces centrosome amplification and aneuploidy and it is related with cancer progression and poor prognosis. Here we show that AURKA phosphorylates in vitro the transcripcional co-repressor Ski on aminoacids Ser326 and Ser383. Ph...

BACKGROUND Low protein diets (LPD) have long been prescribed to chronic kidney disease patients with the goals of improving metabolic abnormalities and postpone the start of maintenance dialysis. METHODS We reviewed the recent literature addressing low protein diets supplemented with ketoacids/essential aminoacids prescribed during chronic kidney disease and their effects on metabolic, nutrit...

The genes encoding the heat shock proteins HSP10 and HSP16 of the salmon pathogen Piscirickettsia salmonis have been isolated and sequenced. The HSP10 coding sequence is located in an open reading frame of 291 base pairs encoding 96 aminoacids. The HSP16 coding region was isolated as a 471 base pair fragment encoding a protein of 156 aminoacids. The deduced aminoacid sequences of both proteins ...