The asymmetric unit of the title polymeric mononuclear Cu(II) complex, [Cu(C2N3)2(NH3)2] n , contains one half-mol-ecule, the complex being completed through inversion symmetry, with the Cu(II) atom situated on the centre of symmetry. The coordination polyhedron around Cu(II) is a Jahn-Teller-distorted [CuN6] octa-hedron. The terminal N atoms of two dicyanamide ligands and two ammine ligands fo...

Penta-ammine dioxide uranium(V) nitrate ammonia (1/1), [UO2(NH3)5]NO3·NH3, was obtained in the form of yellow crystals from the reaction of caesium uranyl nitrate, Cs[UO2(NO3)3], and uranium tetra-fluoride, UF4, in dry liquid ammonia. The [UO2]+ cation is coordinated by five ammine ligands. The resulting [UO2(NH3)5] coordination polyhedron is best described as a penta-gonal bipyramid with the O...

Acquired resistance to cisplatin has been generated in vitro in two human ovarian carcinoma cell lines: 41M, established from a previously untreated patient; and CH1, from a patient previously treated with cisplatin and cis-diammine-1,1-cyclobutane dicarboxylatoplatinum(II) (carboplatin). In neither cell line with acquired resistance did intracellular detoxification (via increased glutathione o...

A polarised-neutron diffraction experiment on [Co(NH3)5(H20)][Cr(CN)6] shows the unexpected features of spin populat ions on the cobalt ((0.5(2) e) and the "ammine" hydrogen (0.8(1) e in total) atoms. A local density approximation DV-Xa calculation on a unit that models the molecular geometry in the crystal returns features that are broadly in agreement with the experiment. The calculation also...

Ammine aluminium borohydride system is found to release >12 wt% pure H(2) below 120 °C via a combined strategy of changing the coordination number and adopting mixed cations.

This work presents a systematic theoretical study on Cu(I) and Cu(II) cations in variable hydrogen sulfide-aqua-ammine ligand fields. These ligands model the biologically most common environment for Cu ions. Molecular structures of the complexes were optimized at the density functional theory (DFT) level. Subsequent thorough energy analyses revealed the following trends: (i) The ammine complexe...

The comparative nephrotoxicity of i.v. cisplatin, i.v. carboplatin and six p.o. ammine/amine Pt(IV) dicarboxylates was studied in rodents following single MTD treatments. In mice, i.v. cisplatin caused proteinuria (1 g 'l), glycosuria (16.7 mM) and decreased GFR at 4 days, and histological kidney damage with onset at 6 days. In contrast, mice treated with i.v. carboplatin or p.o. ammine/amine P...