BACKGROUND Numerous studies have indicated that serotonin (5-HT)1B receptor ligands affect the behavioral effects of psychostimulants (cocaine, amphetamine), including the reinforcing activities of these drugs. METHODS To substantiate a role for those receptors in incentive motivation for amphetamine, we used the extinction/reinstatement model to examine the effects of the 5-HT1B receptor lig...

objective: this study aimed to examine the effects of haloperidol and amphetamine on human startle response modulated by emotionally-toned film clips. method: sixty participants, in two groups (one receiving haloperidol and the other receiving amphetamine) were tested using electromyography (emg) to measure eye-blink muscle (orbicular oculi) while different emotions were induced by six 2-minute...

Repeated intermittent amphetamine enhances efflux of dopamine through the dopamine transporter in rat basal ganglia and through the norepinephrine transporter in rat pheochromocytoma PC12 cells. Extracellular Ca2+ is required for the detection of this enhancement in the rat. In this study, we examined the role of Ca2+ and Ca2+ channels in the enhanced amphetamine-induced dopamine efflux that de...

(+/-)-Phenylpropanolamine (PPA), a widely available anorectic and decongestant, was evaluated in several behavioral paradigms rhesus monkeys for central nervous system neurotoxicity rats. PPA (1-30 mg/kg intragastric) reduced food intake but not self-administered i.v. (0.3-10 mg/kg/injection) by experienced drug self-administration. (30-100 resulted amphetamine-like responding two of four train...

Effectiveness of Matrix Treatment on Depression and Temptation in Consumption Amphetamine Dependent Individuals

BACKGROUND: In response to the rising rate of treatment admissions related to illicit use of amphetamines (eg, methamphetamine), we examined the prevalence of amphetamine use among treatment-seeking, opioid-dependent adults, explored whether amphetamine users were as likely as nonamphetamine users to enroll in opioid-dependence treatment trials, and determined whether amphetamine users manifest...

The influence of adenosine receptor agonists and antagonists on amphetamine-induced conditioned place preference (CPP) was examined in male Wistar rats. Selective adenosine A1 receptor agonist, CPA, significantly reduced the acquisition of CPP induced by amphetamine. NECA (A2/A1 adenosine receptor agonist) produced similar effect, but selective A2 adenosine receptor agonist CGS 21680, attenuate...

Repeated, intermittent treatment of rats with amphetamine followed by a withdrawal period leads to an enhancement in amphetamine-induced dopamine release. We previously reported an increased stoichiometry of site 3-phospho-synapsin I and increased levels of phospho-Ser41-neuromodulin in striatum after repeated amphetamine. In this study, we examined whether the enhanced amphetamine-induced dopa...

Methylenedioxymethamphetamine (MDMA) is structurally related to methamphetamine (MA). There are many different commercially available immunoassay (IA) reagents for the initial screening of amphetamine and/or methamphetamine. These reagents may be employed to detect MDA/MDMA in urine samples. In order to select a suitable reagent for the initial screening of MDMA in urine samples, we evaluated 7...

Astrocytosis, a process in which astrocytes undergo proliferation and enhancement of glial fibrillary acidic protein (GFAP) expression, has been suggested to play important roles in the maintenance of dependence to amphetamine and its derivatives. It was previously shown that mice with genetic deletion of pleiotrophin (PTN), a neurotrophic factor upregulated in different brain areas after admin...