SUMMARY AnaGram is a web service for protein function assignment based on identity detection of small significant fragments (protomotifs) that can act as modular pieces in peptide construction. The system is able to assign function by finding correlations between protomotifs and functional annotations contained in SWISS-PROT and Medline databases. In addition, function ontologies are used for h...

This paper describes KOAN and ANAGRAM 11, new tools for device-level analog placement and routing. A block place-and-route style from macrocell digital IC’s has recently emerged as a viable methodology for the automatic layout of custom analog cells. In this nuIcroceU style, parameterized module generators produce geometry for individual devices, a placer arranges these devices, and a router em...

Unscrambling an anagram prior to making a recognition judgement about that target word or an unrelated word increases one’s claims of having seen the target word before (the revelation effect). We examined whether a revelation effect would occur with brand name recognition and preference. When participants had to solve an anagram prior to seeing a target brand, they were more likely to claim to...

introduction: mental sets are clues which are already coded and stored in memory, and retrieved when needed. the present study investigated the role of mental sets in solving anagram problems. methods: the design of this study is an experimental with repeated measurement design. the participants were 20 ma students and graduates chosen through voluntary sampling. each of them were required to u...

Lesion data suggest that right prefrontal cortex (PFC) plays a critical role in open-ended problem solving. To test this hypothesis, we scanned fifteen normal subjects with fMRI as they completed three types of anagram problems varying in the level of constraints placed on the search space. On unconstrained trials, they rearranged letters to generate solutions (e.g., Can you make a "Word with Z...

Primary progressive aphasia (PPA) is a clinical dementia syndrome with early symptoms of language dysfunction. Postmortem findings are varied and include Alzheimer disease and frontotemporal lobar degeneration (FTLD), both tauopathies and TAR DNA binding protein (TDP-43) proteinopathies. Clinical-pathological correlations in PPA are complex but the presence in the clinical profile of agrammatis...

What are the neural correlates of insight solutions? To explore this question we asked participants to perform an anagram task while in the fMRI scanner. Previous research indicates that anagrams are unique in that they can yield both insight and search solutions in expert subjects. Using a single-trial fMRI paradigm, we utilized the anagram methodology to explore the neural correlates of insig...

Biomedical vocabularies have specific characteristics that make their lexical alignment challenging. We have built a string-based vocabulary alignment tool, AnAGram, dedicated to efficiently compare terms in the biomedical domain, and evaluate this tool’s results against an algorithm based on Jaro-Winkler’s edit-distance. AnAGram is modular, enabling us to evaluate the precision and recall of d...