N-methyl-N-nitrosourea (MNU) induces estrogen-dependent mammary tumors in female Lewis rats. We explored the antineoplastic activity of a synthetic androstane derivative, 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235), as a single agent or in combination with docetaxel compared to tamoxifen, anastrazole, and docetaxel monotherapies against MNU-induced mammary tumors in female Lewis rats. Treat...

BACKGROUND Estrogen plays a critical role in breast cancer. Thereafter, endocrine therapy is a standard of care in patients with breast carcinoma, expressing ER or PR. CASE PRESENTATION Herein we report the case of a 53-year old patient, who developed cholestasis and vasculitis during the treatment with tamoxifen. This toxicity was reversable after the removal of the drug. Thereafter she cont...

Female androgenetic alopecia (FAGA) is a common and distressing cause of hair loss, caused by androgens in genetically susceptible women [1, 2], in which dihydrotestosterone (DHT) binds to androgen receptors leading to miniaturization of scalp hair follicles [3]. FAGA, characterized by a specific diffuse loss of hair of the parietal or frontovertical regions ('in the crown'), where 5α-reductase...

OBJECTIVE Third-generation aromatase inhibitors (AI) are potent suppressors of aromatase activity. The aim of this study was to measure the incidence of adverse effects in breast cancer patients treated with AI-based adjuvant therapy and the relationship with the CYP19A1 genotypes. MATERIALS AND METHODS Forty-five postmenopausal breast cancer patients (46-85 yrs) in AI adjuvant treatment were...

Females are more susceptible to pulmonary arterial hypertension than males, although the reasons remain unclear. The hypoglycemic drug, metformin, is reported to have multiple actions, including the inhibition of aromatase and stimulation of AMP-activated protein kinase. Inhibition of aromatase using anastrazole is protective in experimental pulmonary hypertension but whether metformin attenuat...

Endometriosis as a common hormone-dependent gynecologic disease is seen in 10-15% of women of reproductive age. On the other hand, 20-50% of women with infertility have endometriosis and 30-50% women with endometrioma are infertile. One of severe form of endometriosis is endometrioma. Surgery is considered as essential treatment for endometrioma with the recurrence rate of 10%. Many researches ...

The considering both various studies and the EBCTCG meta-analysis, it is reported that therapeutic effect correlated with rate of ER positivity in breast cancer patients receiving endocrine therapy.In this study, was aimed to evaluate percentage HR on treatment response prognosis HR+ HER2- MBC who received CDK 4/6 inhibitor ET. In were followed up treated Dokuz Eylul University Medical Oncology...

The testicular feminized (Tfm) mouse carries a nonfunctional androgen receptor (AR) and reduced circulating testosterone levels. We used Tfm and castrated mice to determine whether testosterone modulates markers of aging in cardiomyocytes via its classic AR-dependent pathway or conversion to estradiol. Male littermates and Tfm mice were divided into 6 experimental groups. Castrated littermates ...