Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide (PPO) flanked by two hydrophilic polyethyleneoxide (PEO) blocks. Among this family of copolymers, poloxamer 407 is a non-ionic surfactant with reversible gelation properties above a particular polymer concentration and a particular temperature. Easy preparation of poloxamer 407 based sterile injectable for...

This paper evaluates a large-scale pilot program run by a company called OPOWER, previously known as Positive Energy, to mail home energy use reports to residential utility consumers. The reports include energy conservation information as well as social comparisons between a household’s energy use and that of its neighbors. Using data from a randomized natural …eld experiment at 80,000 treatmen...

The mating strategies of male and female Ectropis oblique Prout were investigated with the aid of male antennae as an electroantennogram (EAG) detector and capillary-GC analysis. Each male was capable of mating with several females, but females that had received a spermatophore mated only once. Antennae dissected from males 0, 1, 2, 3, and 4 d post-mating and antennae from virgin males of corre...

Human medicine is continuously developing, and human medical model is also constantly evolving. In the evolution process of medical model, medical humanistic spirit is constantly developing as well. In order to build modern medical humanistic spirit, grasp of the evolution of human medical model as well as the development course of medical humanistic spirit is highly necessary. In this paper, t...

Systemic lupus erythematosus (SLE) is a multi-system inflammatory disease where genetic susceptibility coupled with largely undefined environmental factors is reported to underlie the aetiology of the disease. One such factor is low vitamin D status. The primary source of vitamin D is endogenous synthesis following exposure of the skin to UVB light. Photosensitivity, sunlight avoidance and the ...

Insights into the proteome reactivity of electrophiles are crucial for designing activity-based probes for enzymes lacking cognate affinity labels. Here, we show that different classes of carbon electrophiles exhibit markedly distinct amino acid labeling profiles in proteomes, ranging from selective reactivity with cysteine to adducts with several amino acids. These data specify electrophilic c...

Poloxamer 407 (P-407) is a copolymer surfactant that induces a dose-controlled dyslipidemia in both mice and rats. Human macrophages cultured with P-407 exhibit a concentration-dependent reduction in cholesterol efflux to apolipoprotein A1 (apoA1) linked to downregulation of the ATP-binding cassette transporter A1 (ABCA1). Activators of peroxisome proliferator-activated receptor gamma (PPARgamm...

Any symmetric mixed-strategy equilibrium in a Tullock contest with intermediate values of the decisiveness parameter (“ 2)hascountablyinfinitelymanymasspoints.Allprobabilityweightisconcentratedonthosemasspoints, whichhavethezerobidastheirsolepointofaccumulation.Withcontestantsrandomizingoveranon− convexset, thereisacostofbeinghalfhearted, whichisabsentfromboththelotterycontestandtheall−payaucti...