mobile carrier properties of two schiff base ligands, named bis(2-hydroxypropiophenone)-1,2-propanediimine (n2o2) and bis(1'-hydroxy-2'-acetonaphthone)-2,2'-diiminodiethylamine (n3o2), dissolved in dichloromethane for the extraction of copper(ii) ions from an ammonium buffer feed phase into a nitric acid solution (receiving phase) were investigated and compared. the parameters influencing the t...

Many bacterial species protect themselves against environmental F(-) toxicity by exporting this anion from the cytoplasm via CLC(F) F(-)/H(+) antiporters, a subclass of CLC superfamily anion transporters. Strong F(-) over Cl(-) selectivity is biologically essential for these membrane proteins because Cl(-) is orders of magnitude more abundant in the biosphere than F(-). Sequence comparisons rev...

Structural control of Schiff base ligands for selective extraction of copper(II) was investigated by changing pendant arms and the distance between two imine-N donor atoms in ligands. Di-Schiff base ligands, N,N'-bis(2-quinolylmethylidene)-1,2-diiminoethane (BQIE), N,N'-bis(2-pyridylmethylidene)-1,3-diimino-2,2-dimethylpropane (BPMP) and N,N'-bis(2-quinolylmethylidene)-1,3-diimino-2,2-dimethylp...

The high level of conservation in ATP-binding sites of protein kinases increasingly demandsthe quest to find selective inhibitors with little cross reactivity. Kinase kinases are a recently discovered group of Kinases found to be involved in several mitotic events. These proteins represent attractive targets for cancer therapy with several small molecule inhibitors undergoing different ph...

a series of non-cyclic polyethers with different end groups and chain length were used for the extraction of lithium salt from aqueous into various organic phases viz. chloroform, carbon tetrachloride, 1,2-dichloroethane, to study the influence of structural variations within the extractant molecule upon the extraction selectivity and efficiency. the ionophores used were viz. deg (i), degdme (i...

An environmentally benign procedure for the synthesis of vicinal nitrohydrins via the regioselective ring opening reaction of epoxides with nitrite anion using silica-bound 3-{2-[poly(ethylene glycol)]ethyl}-substituted 1-methyl-1H-imidazol-3-ium bromide as an effective heterogeneous phase transfer catalyst was described. Short reaction time, high yield of products, simple work-up proc...

We report that an amphiphilic bis-catechol (3) functions as a transmembrane anion transporter. Activity depends on the catechol's substitution and amphiphilicity. We also describe a liposomal assay that allows one to readily measure anion transport selectivity. This assay reveals that anion transport selectivity for this amphiphilic bis-catechol follows a Hofmeister sequence wherein anions that...

a new series of noncyclic ionophores containing two to four furan units (ia to iiib) i.e. 1,1-difurylethane (ia), 2,5-bis(methylfurfuryl)furan (iia) and 1,1’ ethyledenebis[5-(methylfurfuryl)furan] (iiia), 2,2-difurylpropane (ib), 2,5-bis (dimethylfurfuryl)furan(iib), 2,2’-isopropylidenebis[5-(dimethylfurfuryl)furan] (iiib) have been synthesized by the condensation of furan with acetaldehyde and...