Despite the importance of airway surface liquid pH in the lung's defenses against infection, the mechanism of airway HCO3- secretion remains unclear. Our aim was to assess the contribution of apical and basolateral Cl-/HCO3- exchangers to Cl- and HCO3- transport in the Calu-3 cell line, derived from human airway submucosal glands. Changes in intracellular pH (pHi) were measured following substi...

Because the boiler is developed to the trend of large size, high temperature and high pressure, so the requirement of water quality for the boiler makeup water is higher and higher, and that needs to almost get rid of all salts in the water. So anion-cation exchange technology has been developed quickly. For example, use the H cation exchanger to exchange various cations in the water and give o...

BACKGROUND The mechanism of hypoxic pulmonary vasoconstriction (HPV) is still debatable. It has been proposed that reactive oxygen species (ROS) might be involved in HPV. However, there is no special transporter for superoxide anion in the cell membrane and it may release from the cells via anion exchanger. Therefore, the aim of this study was to investigate the interaction of ROS and anion exc...

The combined effect of both concentration and pressure differences on electrical potential (Ad~) for two ion-exchanger membranes, one positively charged (AE) and another negatively charged (CE), measured with the membranes in contact with NaCI solutions was studied. Results show a linear dependence between Adp and pressure, independently if AC and AP have the same or opposite directions. The ra...

The anion exchanger 1 (AE1) is encoded by the SLC4A1 gene and catalyzes the electroneutral anion exchange across cell plasma membrane. It is the most abundant transmembrane protein expressed in red cell where it is involved in CO(2) transport. Recently, 4 new point mutations of SLC4A1 gene have been described leading to missense mutations in the protein sequence (L687P, D705Y, S731P, or H734R)....

1 A theoretical treatment of potentiometric data is applied to calculate coextraction 2 constants (K IA) for three potassium salts from water into a liquid nitrobenzene phase. 3 The experiment involves treating nitrobenzene as a membrane and contacting it with 4 two aqueous solutions of different ion activities. In the presence of either a cation or 5 anion exchanger, the ratio of activities of...

AE3 gene is a member of the AE anion exchanger gene family that is expressed primarily in brain and heart. The principal product of the AE3 gene in rodent brain, FL-AE3p, when expressed in heterologous cell lines, gives rise to chloride-dependent changes in intracellular pH consistent with its operation as an anion exchanger. We have identified two novel isoforms of mouse AE3 that are generated...

a pvc-based membrane containing cerium phosphate was developed. unlike the cerium phosphate itself that acts as a cation exchanger, the membrane exhibited anion-exchange properties. therefore, the utility of this compound as a sensory element for detection of molybdate ions was pursued. the response of molybdate selective electrode based on this membrane was perfectly linear in the concentratio...

Synthetic and biological living polymers are self-assembling chains whose chain length distributions (CLDs) are dynamic. We show these dynamics are ultrasensitive: Even a small perturbation (e.g., temperature jump) nonlinearly distorts the CLD, eliminating or massively augmenting short chains. The origin is fast relaxation of mass variables (mean chain length, monomer concentration) which pertu...

B R Calder, L M Linnett and D R Carmichael Heriot-Watt University, Scotland and DRA Bincleaves, England