CONTEXT Animal models can be used to investigate manual therapy mechanisms, but testing manipulation in animal models is problematic because animals cannot directly report their pain. OBJECTIVE To develop a rat model of inflammatory joint injury to test the efficacy of manual therapy in reducing nociception and restoring function. METHODS The authors induced acute inflammatory joint injury ...

AIM To study the therapeutic effect of three tube-guides with electrical conductivity associated to mesenchymal stem cells (MSCs) on neuro-muscular regeneration after neurotmesis. METHODS Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol (PVA), PVA-carbon nanotubes (CNTs) and MSCs, and PVA-polypyrrole (PPy). The regenerated nerves and tibialis anterior muscles were processe...

background ankle injuries are one of the most common presentations in emergency department. ottawa ankle rules (oars) have been used to predict the requirement of radiographs. objectives this study aimed to validate the oars protocol for predicting ankle and midfoot fractures in indian population. patients and methods a prospective study was conducted in a teaching hospital in north india, duri...

OBJECTIVE Our previous research has concerned the role of macrophages in joint inflammation in rheumatoid arthritis. We have therefore been interested in liposomes containing clodronate as an antimacrophage treatment for arthritis. We have used the antigen-induced arthritis model in sheep to evaluate the effect of clodronate liposomes. METHODS Arthritis was induced in the right hock joint (da...

conclusions the os trigonum syndrome should take in consideration in elderly subject who had posterior ankle pain starting after a car accident. case presentation a 62-year-old female patient was admitted with load depended ankle pain and swelling, lasting for five years which promptly started after a car accident. we incidentally discovered os trigonum on plain radiography on a lateral view of...

Synovial chondromatosis of the ankle is rare and sparsely documented. Traditional surgical intervention is open loose body excision and synovectomy. Upon literature review, only two other cases were found to be managed arthroscopically. We report a case of synovial chondromatosis in a 54-year-old man leading to pain and limited range of motion of his ankle. This unique case of extensive nodule ...

purpose ankle sprain is one of the most common injuries among athletes and instability and injury to this joint is responsible for long time loss of physical and recreational activity. also, it can impose high costs to sport teams. prevention of this injury is an important concern of practice and rehabilitation. one way of reducing the possibility of ankle joint injury is using an ankle orthosi...

BACKGROUND We examined whether low-grade albuminuria, below the conventional cut-off value for microalbuminuria, was associated with atherosclerotic vascular diseases in 8897 community-dwelling Koreans aged ≥50 years. METHODS The urinary albumin-to-creatinine ratio (UACR) was calculated using random spot urine. Common carotid artery (CCA) intimamedia thickness (IMT) and CCA internal diameter ...

Bruton's tyrosine kinase (BTK) plays a critical role in the development, differentiation, and proliferation of B-lineage cells, making it an attractive target for the treatment of rheumatoid arthritis. The objective of this study was to evaluate the antiarthritis effect of GDC-0834 [R-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylpheny...