A patient with previously diagnosed ankylosing spondylitis developed a first episode of peripheral synovitis following enteritis with Salmonella group D. Ankylosing spondylitis and reactive arthritis are HLA-1B27-related conditions and flare-ups have been linked to alterations in bowel flora. This case report supports recent suggestions that peripheral synovitis in ankylosing spondylitis is a f...

Ankylosing spondylitis is a chronic inflammatory multisystem disease that primarily affects the axial joints. Pleuropulmonary involvement is an uncommon extra-articular manifestation of ankylosing spondylitis. There is a wide spectrum of pulmonary parenchymal changes in ankylosing spondylitis, beginning in the early stages of the disease and increasing over time. The lesions are usually asympto...

[Purpose] This study aimed to compare the most common dominant affective temperaments in Ankylosing Spondylitis patients and investigate the relationship between the dominant affective temperaments and pain levels, disease activity, quality of life, current depression, and anxiety level in Ankylosing Spondylitis patients. [Subjects and Methods] Fifty-one patients diagnosed with axial spondiloar...

INTRODUCTION Disease progression of ankylosing spondylitis has been considered irreversible. However, we report a case of spontaneous regression of syndesmophyte development following allogeneic peripheral blood stem cell transplantation in a patient with acute myeloid leukemia, who was also diagnosed as having ankylosing spondylitis. To the best of our knowledge, this is the first case report ...

One hundred and twenty-eight of 145 patients with ankylosing spondylitis (AS) were found to be HLA B27 positive. Five patients had evidence of a sero-negative peripheral arthritis resembling peripheral psoriatic arthritis and 3 of these were B27 negative. One further B27 negative patients had a sister with ankylosing spondylitis and ulcerative colitis and a mother with ulcerative colitis. There...

Using a standard microcytotoxicity (NIH) technique of tissue typing, the HLA-B27 antigen was identified in 30 out of 34 patients (HH.2%) with classical ankylosing spondylitis (AS), compared to 6 out of 70 controls (H.6%) (P < 0.005). We also found this antigen in 8 out of 76 (10.5%) patients with non-AS arthritis.

This editorial refers to ‘Looking Ahead: Best Practice for the Care of People with Ankylosing Spondylitis (AS)’, published by the National Ankylosing Spondylitis Society. The conclusions are underlined by the accompanying paper, ‘Services for people with ankylosing spondylitis in the UK—a survey of rheumatologists and patients’, by Louise Hamilton et al., doi:10.1093/rheumatology/ker013, on pag...

OBJECTIVE To assess basal function and responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis in patients with ankylosing spondylitis during dynamic testing. METHODS Insulin induced hypoglycaemia (IIH) (Actrapid HM 0.1 IU/kg, as intravenous bolus) was induced in 17 patients and 11 healthy controls matched for age, sex, and body mass index. Concentrations of glucose, adrenocorticotrop...

PURPOSE OF REVIEW The past 18 months has seen considerable advances in the use of MRI for assessment of ankylosing spondylitis, to quantify active inflammation in the spine and sacroiliac joints which may not otherwise be detectable and to therefore measure change due to therapeutic interventions. RECENT FINDINGS Characterization of the extension and morphology of inflammation in ankylosing s...

background and aims: ankylosing spondylitis (as) is an idiopathic chronic inflammatory disease mainly involves sacroiliac and axial joints; but it may also have extra-articular involvement. accordingly, this study was designed to determine the frequency of cardiac involvement among patients with ankylosing spondylitis. methods: this study was performed as a descriptive-analytical cross-section...