effects of petroleum ether and ethanolic extracts of trichilia monadelpha stem bark (pee and eae) on compound 48/80-induced systemic and passive anaphylaxis were determined. survival rate, extravasation, degranulation of mast cells, and secretion of tumour necrosis factor-α (tnf-α) and interleukin-6 (il-6) were measured after pre-treatment with extracts (10-100 mg/kg) and disodium chromoglycate...

BACKGROUND Peanut allergy is characterized by increased levels of peanut-specific IgE in the serum of most patients. Thus, the most logical therapy would be to inhibit the IgE production by committed B-cells. This study aims to investigate the unreported anti-IgE effects of Chinese herbal extracts of Rubia cordifolia (Qiancao) and Dianthus superbus (Qumai). METHODS Seventy herbal extracts wer...

BACKGROUND Asthma is a chronic inflammatory disorder of the airways. The available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. Therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. Myrica sapida is known traditionally in ...

Glycosylation of the Ab molecule is essential for maintaining the functional structure of Fc region and consequently for Ab-mediated effector functions, such as binding to cells or complement system activation. Alterations in the composition of the sugar moiety can dramatically influence Ab activity; however, it is not completely clear how differences in the N-linked oligosaccharide structure i...

Anaphylactic transfusion reactions are acute, potentially life-threatening events with generalized signs and symptoms. Usually IgE mediated they may also result from antigen -antibody reaction involving non-IgE antibodies which fix complement and generate anaphylatoxins. The best documented reactions of the latter type result from presence of anti IgA antibodies in IgA deficient patients who re...

Drug therapies grow more complex, thus a wide range of drug-related problems (DRPs) may arise. Adverse drug reactions (ADRs) are responsible for approximately 10% of all DRPs. The most severe form of ADR is an anaphylactic shock. It is estimated that severe anaphylaxis affects annually 1–3 per 10 000 people and causes death of 0.65–2% of those patients, i.e. 1–3 per 1 000 000 people. Fatal drug...

Anaphylactic shock in the dog, caused by the intravenous injection of horse serum into sensitized animals, may produce definite cardiac disturbances which are revealed by the electrocardiogram. These cardiac changes consist of disturbances in conduction of the heart impulses, abnormalities in the ventricular contractions, and other unusual disturbances of the mechanism of the heart-beat. They c...

severe allergic reactions during specific immunotherapy may occur in the treatment of hymenoptera sting allergy. the objective of the present study was to examine the characteristics of allergic reactions during specific immunotherapy in patients with allergy towards hymenoptera venom in the iranian population. a prospective study was performed using the clinical reports of 27 patients with ana...