Objectives: The present study was undertaken for investigating the protective effect of ethanolic extract of Mirabilis Jalapa Linn leaves on antitubercular drugs induced hepatotoxicity. Methods: Anti-tubercular drugs were used to induce hepatotoxicity in rats. Silymarin was used as standard drug (100 mg/kg p.o.). Ethanolic extract of leaves of Mirabilis Jalapa Linn (250 & 500 mg/kg p.o.) was ad...

BACKGROUND The emergence of drug-resistant strains of Mycobacterium tuberculosis has become a global public health problem. Polyherbal medicines offer great hope for developing alternative drugs for the treatment of tuberculosis. OBJECTIVE To evaluate the anti-tubercular activity of polyherbal medicines used for the treatment of tuberculosis. METHODS The remedies were screened against Mycob...

in the present study, quantitative relationships between molecular structure and anti-tubercular activity of some 5-methyl/trifluoromethoxy-1 h -indole-2,3-dione-3-thiosemicarbazone derivatives were discovered. the detailed application of an efficient linear method and principal component regression (pcr) for the evaluation of quantitative structure activity relationships of the studied compound...

We report a 38-year-old Chinese woman with lupus nephritis on peritoneal dialysis and long-term maintenance steroid therapy. This patient developed paradoxical deterioration during anti-tubercular therapy for tuberculous lymphadenitis. The deterioration resolved spontaneously without change to pharmacotherapy. Paradoxical deterioration that may spontaneously resolve is a potential complication ...