OBJECTIVES To establish an experimental platform in Staphylococcus aureus for identifying genetic loci that determine intrinsic antibiotic susceptibility and/or that have the potential to contribute to acquired antibiotic resistance. A near-saturation S. aureus transposon (Tn) library was screened for mutants exhibiting altered susceptibility to the antistaphylococcal agents daptomycin, vancomy...

The in vitro antibacterial activities of oral cephem antibiotics and ketolide telithromycin against major respiratory pathogens possessing beta-lactam-resistant mutations (within the pbp gene) and/or macrolide-resistant genes (erm and mef) were examined in clinical isolates collected at 66 institutes in all over the Japan between 2002 and 2003. Telithromycin showed the strongest antibacterial a...

The major ingredient of Cinnamomum, which is cinnamic aldehyde, has a variety of uses, such as aromatic compound, beverage, chewing gum, toothpaste, and incense as a component of cosmetics, and halitosis remover. Cinnamic aldehyde is also known to have a remedial effect. In this study, Cinnamomum is used to look for antibacterial activity on oral bacteria. A disk diffusion method is used as the...

BACKGROUND Multi-drug resistant (MDR) bacteria have become a major concern in hospitals worldwide and urgently require the development of new antibacterial molecules. Peptide deformylase is an intracellular target now well-recognized for the design of new antibiotics. The bacterial susceptibility to such a cytoplasmic target primarily depends on the capacity of the compound to reach and accumul...

BACKGROUND The recent report of high numbers of Acinetobacter baumannii bloodstream infections among service members injured in Iraq and Afghanistan during the period January 2002 through August 2004 has prompted an investigation into their etiology. A review of the current guidelines for open combat casualty wounds as part of this broad investigation was not mentioned in the report. OBJECTIV...

background: despite the discovery of numerous antibiotics, drug resistance still remains as a major problem. therefore, it is important to introduce and replace new sources of drug such as medicinal plants with antimicrobial properties. objective: the genus clematis (ranunculaceae family) has six species in iran. aerial parts of clematis have been used to cure fever and chronic diseases such as...

The purpose of the present study to examine the antibacterial and cytotoxic properties of ethanol extract of leaves of Mikania cordata (Burm.f.) B.L. Robinson. To determine antibacterial activities, the extract was tested against four Gram positive and six Gram negative bacteria at three concentrations (500, 800, 1000 μg disc(-1)) through disc diffusion method. The extract showed moderate antib...

To make use of nano-sized particles for biomedical applications such nanomedicines for different diseases, it is important to study how nanoparticles behave when they interact with microorganisms. In the present study, we investigated the antibacterial performance of chromium oxide nanoparticles (Cr3O4 NPs) against two gram negative bacterial strains, Escherichia coli, and Pseudomonas aeruginos...

Bacteriolyses of bacterial cell walls by zinc (II) ions on the basis of the results of halo antibacterial susceptibility tests were investigated for the nitrate and the sulfate solutions. From the results obtained by halo antibacterial tests of sulfate solutions against Staphylococcus epidermidis, the antibacterial order is Zn2+>Cu2+>Ag+>Al3+, in which Zn2+ ions indicate the highest antibacteri...