This investigation examined the effect of the anthracycline antitumor agents on reactive oxygen metabolism in rat heart. Oxygen radical production by doxorubicin, daunorubicin, and various anthracycline analogues was determined in heart homogenate, sarcoplasmic reticulum, mitochondria, and cytosol, the major sites of cardiac damage by the anthracycline drugs. Superoxide production in heart sarc...

We have isolated PF1092A, B, and C, novel nonsteroidal progesterone ligands with preferential affinity for the progesterone receptor, from fermentation broth of a fungus [Tabata Y, Miike N, Hatsu M, Kurata Y, Yaguchi T, Someya A, Miyadoh S, Hoshiko S, Tsuruoka T, and Omoto S (1997) J Antibiot 50:304-308; Tabata Y, Hatsu M, Kurata Y, Miyajima K, Tani M, Sasaki T, Kodama Y, Tsuruoka T, and Omoto ...

A summary of recent investigations of the duocarmycins is provided including the total synthesis of (+)-and ent-(-)-duocarmycin SA, the preparation and evaluation of the minimum potent pharmacophore of the alkylation subunit constituting the common pharmacophore of duocarmycin A and SA, the definition and characterization of the DNA alkylation properties of the agents and their correlation with...

Rinehart, K. L., Jr., Cook, J. C., Jr., Maurer, K. H. & Rapp, U. (1974) J. Antibiot. 27, 1-13 Rouse, D. J. & Brent, D. A. (1974) Biomed. Mass Spectrorn. 1,256-262 Sammons, M. C., Bursey, M. M. &Brent, D. A. (1974) Biomed. Mass Spectrom. 1,169-171 Schulten, H.-R. (1974) Biomed. Mass Spectrom. 1,223-230 Schulten, H.-R. & Beckey, H. D. (1973a)J. Chromatogr. 83,315-320 Schulten, H. R. & Beckey, H. ...

(24) Kenknight, C. E. Acta Crystallogr. 1984, A40, 708-712. (25) Ghose, A. K.; Crippen, G. M. J . Comput. Chem. 1985, 6, 350-359. (26) Lejeune, J.; Michael, A,; Vercauteren, D. P. J . Comput. Chem. 1986, 7, 739-744. (27) Stouch, T. R.; Jurs, P. C. J . Chem. In$ Comput. Sci. 1986,26,4-12. (28) Hansch, C.; Leo, A. Substituent Constants for Correlation Analysis in Chemistry and Biology; Wiley: New...

In 1996, Serratia marcescens KU3838 was isolated from the urine of a patient with a urinary tract infection at a hospital in northern Japan and was found to contain the plasmid pKU501. Previously, we determined that pKU501 carries bla(IMP) and the genes for TEM-1-type beta-lactamases as well as producing both types of beta-lactamases (H. Yano, A. Kuga, K. Irinoda, R. Okamoto, T. Kobayashi, and ...

conclusions in the present study, we found a high prevalence of mrsa at the hospitals studied. the findings emphasized the increased prevalence of mrsa isolates containing different toxin and adhesion genes, probably accompanied by antimicrobial resistance. infection with such isolates worsens the clinical outcomes as well as the morbidity and mortality rates in hospitalized patients in icus. m...

We have recently isolated tirandamycin (TAM) B from Streptomyces sp. 17944 as a Brugia malayi AsnRS (BmAsnRS) inhibitor that efficiently kills the adult B. malayi parasites and does not exhibit general cytotoxicity to human hepatic cells. We now report (i) the comparison of metabolite profiles of S. sp. 17944 in six different media, (ii) identification of a medium enabling the production of TAM...

Submitted for the MAR13 Meeting of The American Physical Society Computational NMR, IR/RAMAN calculations in sodium pravastatin: Investigation of the Self-Assembled Nanostructure of Pravastatin-LDH (Layered Double Hydroxides) Systems1 PHILIPPE PETERSEN, VANESSA CUNHA, MARCOS GONÇALVES, HELENA PETRILLI, VERA CONSTANTINO, Universidade de Sao Paulo, INSTITUTO DE F́ıSICA, DEPARTAMENTODE F́ıSICA DEMAT...