Antibiotic-loaded beads have been used widely for the treatment of local bacterial infections, but many bacterial pathogens have become resistant to antimicrobial agents. Various antibiotic beads were prepared and studied for their efficacy to treat bacterial infections, using the elution profiles of enrofloxacin from calcium sulfate beads in vitro. The beads were prepared by mixing 1.0 g enrof...

BACKGROUND Chitosan is a naturally occurring biopolymer which has been widely used in a variety of biomedical applications including local antibiotic delivery due to its excellent mechanical properties, biodegradability and biocompatibility. Beads are spherical, porous carriers which are prepared from various materials including chitosan. OBJECTIVES The current study aimed to fabricate a new ...

357  Abstract Infectious complications of left ventricular assist devices (LVAD) are associated with increases in morbidity, mortality, and hospital costs. Traditional treatment options include intravenous antibiotics, operative debridement, and pump exchange. Herein, we report the case of a 70-year-old female who developed a LVAD pocket infection two weeks after implantation and was successfu...

Streptomycetes, soil-dwelling mycelial bacteria, can colonise surface of organic soil debris and soil particles. We analysed the effects of two different inert surfaces, glass and zirconia/silica, on the growth and antibiotic production in Streptomyces granaticolor. The surfaces used were in the form of microbeads and were surrounded by liquid growth media. Following the production of the antib...

There have been many investigations on non-biodegradable materials acting as an antibiotic carrier for local drug delivery systems based on polymethyl methacrylate (PMMA) beads. However, the material is non-degradable and non-porous so that less than 5% of the encapsulated drug is released. In order to obtain better release of the antibiotics, greater porosity of the beads would be required. Ad...

The use of calcium sulfate beads (CSBs) as a carrier for local delivery antibiotics is increasingly reported the treatment localized infections. They are used most commonly in bone and joint infections, post-trauma diabetes-related foot wounds, vascular grafts. Hypercalcemia rarely with CSB but an important safety concern, patients at higher risk should be identified prospectively followed care...