Thiazolidinedione is an important target for Antidiabetic drugs. There is still significant potential for designing new chemical entity with affordable, safe and efficacious Antidiabetic drug. In present study 2-thioxo4-thiazolidinedione derivatives were designed and interaction of these was investigated by docking studies in the binding site of PPARγ using (PDB ID 1FM9) enzyme using Glide v 5....

Objective of the study was to assess the antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats. Methods: The antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats was assessed using Alloxan βcytotoxin induced chemical diabetes in a wide variety of wister albino rats. Result: The polyherbal formulation contain the following plants leaves ...

AIM Sheep milk-born bioactive peptides have been found to exhibit various physiological activities. The present work was designed with the aim to evaluate the effect of boiling on antidiabetic property of peptides derived from sheep milk caseinate on hydrolysis with three different proteases. MATERIALS AND METHODS In this investigation, casein prepared from raw and boiled sheep milk was hydro...

Present study was aimed to isolate and evaluate the antidiabetic activity of phytoconstituents from fruit rinds of Punica granatum. With the above objectives Valoneic acid dilactone (VAD) was isolated from methanolic fruit rind extracts of Punica granatum (MEPG) and confirmed by (1)H-NMR, (13)C-NMR, and mass spectral data. Antidiabetic activity was evaluated by Aldose reductase, α-amylase and P...

bilberry [vaccinium myrtillus linn. (ericaceae)] fruit (vmf) has been traditionally used for treatment of bladder stones, biliary disorders, scurvy, coughs, and lung tuberculosis. vmf may have some pharmaceutical properties owing to these uses, but in vivo and in vitro studies are limited for clarification of medicinal activity and its antidiabetic and antioxidant properties are not investigate...

The antidiabetic activity of Balanites roxburghii was carried out in normal and alloxan-induced diabetic rats. Oral administration of methanolic extract of kernals (0.1 and 0.3g/kg body weight) significantly lowered the blood glucose levels. The activity can be attributed to reducing the intestinal absorption of glucose. The activity reported was dose-dependent.

background & aim: solenostemon monostachyus has remain invincible in ibibio ethnomedicine for the management of numerous ailment including diabetes mellitus. many of these ethnomedicinal claims are yet to be pharmacologically verified. the purpose of this study therefore was to subject the extract/fractions of solenostemon monostachyus used in folkloric management of diabetes to scientific ...

OBJECTIVES Bidens species are used for their antidiabetic properties traditionally in many countries. Aim of this study is to evaluate hypoglycaemic and antidiabetic activity of Bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. MATERIALS AND METHODS Hypoglycaemic effects of B. tripartita extract and its sub-extracts were investigate...