BACKGROUND/AIMS Dipeptidyl peptidase-4 (DPP-4) inhibitors have pleiotropic effects on cardiovascular protection beyond the antidiabetic property. However, it remains unknown that the impact of one DPP-4 inhibitor sitagliptin on the survival of mesenchymal stem cells (MSCs) in hypoxia and serum deprivation (H/SD) environment. METHODS The apoptosis and autophagy of MSCs were analyzed in differe...

The objective of the study was to investigate the antidiabetic action of aqueous extract of Cassia glauca leaf in different models of rats. The antidiabetic activity of aqueous extract of Cassia glauca leaf was evaluated by using normal and streptozotocin-induced diabetic rats. After the oral administration of aqueous extracts at doses of 500 mg/kg body weight, blood glucose levels and body wei...

objective(s): bidens species are used for their antidiabetic properties traditionally in many countries. aim of this study is to evaluate hypoglycaemic and antidiabetic activity of bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. materials and methods: hypoglycaemic effects of b. tripartita extract and its sub-extracts were investiga...

the current epidemic of diabetes indicates the need of proper and effective medications that are limited in their potency to have many side effects. thus, introduction of alternative and complementary medicine is now in picture. the main objective of this study was to analyze the rate of glucose transport across cell membrane in yeast cells system in the presence of the ethanolic extract of bru...

Since, we previously demonstrated that sequentially extracted methanolic fraction showed marked antioxidant and antidiabetic property in vitro, the present study was design to evaluate the beneficial effects of Phyllanthus virgatus methanolic extract and its partially purified fraction on hyperglycemia and hyperlipidemia in streptozotocin (STZ) induced diabetic rats. The plant extract was subje...

Hydrazine functionalized Schiff base, 1,2-di(benzylidene)hydrazine has been synthesized through a condensation between hydrazine and benzaldehyde under reflux, structurally characterized. The crystal structure analysis reveals that the base crystallizes in an orthorhombic system with Pbcn space group. Crystal data for C14H12N2: = 13.130(2) Å, b 11.801(2) c 7.5649(16) V 1172.1(4) Å3, Z 4, T 298....

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Chromolaena odorata (Family: Asteraceae) synonyms as Eupatorium odoratum is a traditional medicinal plant that is widely used for its wound healing property. In particular, the several parts of this herb have been used to treat wounds, burns, and skin infections. Furthermore, it has also been shown to possess anticancer, antidiabetic, anti-hepatotoxic, anti-inflammatory, antimicrobial, and anti...

The capsaicin is an ingredient that we normally mix in food in many cultural cuisines even in fresh and dried production. Because of its anticancer, anticholesterolemic, antidiabetic, antihypertensive, anti-inflammatory, antimicrobial, and antioxidant properties, capsaicin is used worldwide. Moreover, capsaicin is also used for the protection of cardiovascular and hepatic diseases. The electron...

fruit and leaves of junipers are commonly used internally as tea and pounded fruits are eaten to lower blood glucose levels in anatolia. thus, we aimed to evaluate antidiabetic and antioxidant potential and the chemical profile of juniperus foetidissima willd. and j. sabina l. in this study. in-vitro antidiabetic activities of leaf and fruit extracts were examined by their inhibitory activity o...