Two antigen-antibody systems were Out of 42 sera from patients with acute viral hepatitis 33 were positive for HBsAg,all HBsAg positive individuals possessed anti-HBc. From 11 blood donors  sera 8 were positive for HBsAg and 9 were Positive for anti-HBc;2 leprosy sera were tested,both of them were positive for HBsAg and anti-HBc. 5 miscellaneous sam­ples,z·were positive for HBsAg and anti-HBc...

unresponsiveness to hepatitis b surface antigen (hbsag) has been shown to be associated with dysfunction of the presenting cells (apc) and defect in the specific b-lymphocyte and/or t-lymphocyte repertoires.   direct determination of the frequency of specific t-lymphocytes together with complementary analysis of the naive circulating immune cells could provide valuable information about the cel...

Background: Platelets can activate B cells and stimulate them for the production of antibodies. Since platelet microparticles (PMPs) originate from platelets, they may have the same virtue. In the present study, the effect of PMPs was investigated on the production of human leukocyte antigen (HLA)-specific antibody from B cells in vitro. Materials and Methods: In this experimental study, HLA-D...

Idecabtagene vicleucel (ide-cel, also called bb2121), a B-cell maturation antigen–directed chimeric antigen receptor (CAR) T-cell therapy, has shown clinical activity with expected CAR toxic effects in patients relapsed and refractory multiple myeloma.

background : the current study was designed to evaluate immune responses induced by dna vaccines encoding 8-kda subunit of antigen b (hydi) of echinococcus granulosus and murine interleukin 12 (il-12) as genetic adjuvants in balb/c mice. methods : expression plasmid pcdna3.1 containing hydi (pchyd1) as vaccine along with the murine interleukin 12 (pcmil12) as adjuvant were used. thirty-five mic...

we measured the prevalence of hbv surface antigen (hbsag) among male injection drug users (idus) in detention, tehran, iran. a cross-sectional survey included 499 male idus arrested by police during a predetermined police sweep in tehran (february, 2006). a questionnaire was filled out for each individual. blood specimens were collected for hbsag testing. prevalence of hbsag was 5.8% (95% ci 3....

The genome of HB V virus of serotype ayw cloned in pBR322 and expression shuttle vector p YES2 were used for construction of the HBsAg chimeric genes and their expression in Saccharomyces cerevisiae. Two recombinant plasmids were constructed. One of them contained the coding sequences for the major polypeptide of surface antigen. Another construct carried the major polypeptide with the pre-S2 a...

abstract background: hepatitis b virus (hbv) infection in patients who lack detectable hepatitis b surface antigen (hbsag) is called occult hepatitis b infection. such infections have been frequently identified in patients with chronic hepatitis cliver disease, but their prevalence is not known. methods: 207 patients with chronic hepatitis c who were hcv -rna and antihcv positive were studied f...