Objective(s): The purpose of this study was preparation and evaluation of PLGA nanospheres containing the influenza virus and different adjuvants, Quillaja saponin (QS) and CpG-ODN.   Materials and Methods: Nanospheres were prepared using the double emulsion-solvent evaporation method. The morphological and physicochemical properties were studied by scanning electron microscopy...

Poor distribution of antigen/adjuvant to target sites and inadequate induction of T cell responses remain major challenges in cancer immunotherapy because of the lack of appropriate delivery systems. Nanocarrier-based antigen delivery systems have emerged as an innovative strategy to improve vaccine efficacy. Here we present polymeric hybrid micelles (PHMs) as a simple and potent antigen/adjuva...

An increasing number of infertile, hepatitis B virus-infected individuals have opted for assisted reproductive technology. However, the impact of the hepatitis B virus carrier serostatus on neonatal outcomes has not been evaluated. Data from 504 patients who delivered singletons were analyzed. In females, hepatitis B surface antigen, hepatitis B e antigen, and antibody to hepatitis core antigen...

DNA-based materials have attracted interest due to the tunable structure and encoded biological functionality of nucleic acids. A simple general approach synthesize with fine control over morphology bioactivity is important expand their applications. Here, we report synthesis particles via supramolecular assembly tannic acid (TA) DNA. Uniform different morphologies are obtained using a variety ...

Most infectious diseases are caused by pathogenic infiltrations from the mucosal tract. Nowadays, the use of vaccines has been widely investigated for the prevention of different infectious diseases, infertility, immune disorders, malignancies, and allergies. Broad-spectrum adjuvant substances have been studied for immune system stimulation with a greater efficiency against specific antigens. V...

objective(s): an efficient vaccine against tb is an urgent need. tb peptides are safe candidate but they are weak immunogens and needs to be potentiated by adjuvant/delivery systems. the main purpose of the present study was to determine the potential of cht based nps containing esat-6 antigen of m. tuberculosis for inducing mucosal and systemic immune responses after intranasal and subcutaneou...

In recent years, chitosan nanoparticles have been studied widely for protein delivery. In this study, Hemiscorpius lepturus (HL) venom was encapsulated in chitosan nanoparticles. The aim of the present work was to carry out a systematic study for preparing biocompatible and biodegradable nanoparticles for loading HL scorpion venom and to evaluate their potential as an antigen delivery system. I...

In recent years, use of biodegradable polymers based nanoparticles has received highinterest in the development of vaccines delivery vehicles. The aim of study was to preparechitosan nanoparticles (CS NPs) for loading Echis carinatus (EC) venom and evaluate theirpotential as an adjuvant and antigen delivery system on a pilot scale. CS NPs were preparedusing ionic gelation method, and their char...

Available online 28 January 2016 pathways for cross-presentation to CD8 T cells and presentation to CD4 T cells, respectively. Initial DC targeting studies used the model antigens HEL and Ova conjugated to anti-DEC-205 antibodies resulting in CD4 and CD8 T cell Vaccination is one of the greatest success stories in medicine. responses inmurinemodels (Hawiger et al., 2001). Since then, amyriad Ef...