Benzimidazole is one of the most important heterocyclic groups manifesting various biological properties, such as antibacterial, antifungal, antimicrobial, antiprotozoal and antihelmintic activities. Several benzimidazole derivatives are also active as inhibitors of type I DNA topoisomerases. In this study, three 1H-benzimidazole derivatives with different electronic characteristics at position...

Millingtonia hortensis Linn. (Bignoniaceae) commonly known as Cork tree, Akash neem, Neem chameli. It is an important medicinal plant in Southern Asia ranging from India, Burma, Thailand and Southern China. Cultivated in most parts of India in gardens and avenues. It can grow up to 25 meter tall. Flowers have very rich and pleasant scent, used in the treatment of asthma, sinusitis, cholagogue, ...

Benzimidazole is one of the most important heterocyclic groups manifesting various biological properties, such as antibacterial, antifungal, antimicrobial, antiprotozoal and antihelmintic activities. Several benzimidazole derivatives are also active as inhibitors of type I DNA topoisomerases. In this study, three 1H-benzimidazole derivatives with different electronic characteristics at position...

The development of anthelmintic resistance in sheep gastrointestinal nematodes to commercial anthelmintics has led enormous economic losses many parts the world. For this reason, new sustainable strategies for control these parasites are being actively searched, which include use different alternatives such as plant essential oils. aim study was determine chemical composition oil coriander (Cor...

Molecular docking is the identification of ligand’s correct binding geometry i.e pose in site and estimation its affinity for rational design drug molecule. The current study endeavored high throughput insilico screening 24 compounds docked with their respective protein using PyRx-Virtual Screening Tool software. Out compounds, almost all test showed a very good score. Fluconazole was used as s...

Medicinal plants have remained the major sources of drugs; in fact many of the Currently available drugs were derived either directly or indirectly from them. The Approach to new drugs through natural products has proved to be the single most successful strategy for the discovery of new drugs. In the past decade, research has been focused on scientific evaluation of traditional drugs of plant o...

Benzimidazole, which is a heterocyclic nucleus, plays an important role in various medicines. A number of therapeutic agents such as H1 antihistaminic agent clemizole, a potent opioid analgesic etonitazene, nonnucleoside antiviral compound enviroxime, for promotion of excretion of uric acid irtemazole, non sedating antihistaminic agent astemizole, anti ulcer drugs omeprazole and pentoprazole, a...

Toona ciliata is the plant mainly distributed in sub Himalayan tract. Traditionally, it is useful in chronic dysentery, leprosy, cures fever, headache, blood complaints, cardiotonic, aphrodisiac, and ulcer. Toona ciliata is traditionally used in menstrual disorders. The phytoconstituents present in the plants including triterpenoids, cedrelone, polyynes, limonoids, siderin, steroids etc. Pharma...