Objective: To study the antianaphylactic, antihistaminic and mast cell stabilization activity of Bresol (HK-07) in experimental animals. Materials and Methods: Experimental studies of Bresol (HK-07) were evaluated using Wistar rats and Duncan Hartley guinea pigs. The antianaphylactic activity of Bresol (HK-07) was investigated in rats using active anaphylaxis model. The effect of Bresol (HK-07)...

The Unani eye drop is an ophthalmic formulation prepared for its beneficial effects in the inflammatory and allergic conditions of the eyes. In the present study, the Unani eye drop formulation was prepared and investigated for its anti-inflammatory and antihistaminic activity, using in vivo and in vitro experimental models respectively. The Unani eye drop formulation exhibited significant anti...

Dolichos biflorus Linn. (FamilyFabaceae) is commonly known as ‘Horse gram’. The seeds are used in the treatment of piles, pain, constipation, wounds, urinary calculi, cough, edema, and asthma. The present study was therefore designed for evaluation of antihistaminic activity of seeds of Dolichos biflorus in the management of asthma. Antihistaminic activity of ethanolic extract of Dolichos biflo...

Fluorescein as an Indicator of Antihistaminic Activity: Inhibition of Histamine-induced Fluorescence in the Skin of Human Subjects: Samuel C. Bukantz and Gustave J. Dammin 224 Effect of Hormone on Root Formation in Artocarpus communist: Thomas J. Muzik ...... 225 The Inhibition of Virus Increase by Malachite Green: William N. T kahashi .................................... 226 Stability of Solut...

The alkali preparation of the root and fresh leaf juice of Moringa oleifera possessed significant dose -depen-dent anti-ulcer activity in experimentally induced acute gastric ulcers with aspirin, the anti-ulcer effect of the alkali preparation of the root seems to be more pronounced than that of the fresh leaf juice. Te anti-ulcer activity of the alkali preparation of the root could be due to i...

Histamine is an β–imidazolylethylamine derivative that is present in essentially all mammalian tissues. The major physiological actions of histamine are centered on the cardiovascular system, nonvascular smooth muscle, exocrine glands and the adrenal medulla. In a general sense, histamine plays an important role as a “chemical messenger” component of the various pathways that have evolved in mu...

Purpose: To synthesize a new series of 1-substituted-4-(pyridin-4-yl) [1,2,4] triazolo[4,3-a]quinazolin5(4H)-ones and evaluate them for H1-antihistaminic activity with negligible side effects in guinea pigs. Methods: The synthesized compounds were characterized by Infrared spectroscopy (IR), proton nuclear magnetic resonance (H-NMR) and mass spectrometry (MS) data. The purity of the compounds w...