Despite the great strides made in the understanding and management of diabetes, the disease and diseaserelated complications are increasing unabated. Phytochemicals identified from traditional medicinal plants are presenting an exciting opportunity for the development of new types of therapeutics. Our research group has explored the possible mechanisms of antidiabetic action of two medicinal pl...

AIMS/INTRODUCTION We compared clinical characteristics in patients with type 2 diabetes for whom different antihyperglycemic agents were prescribed as monotherapy or combination therapy by diabetes specialists in Japan. MATERIALS AND METHODS Prescription data for 2005, 2008 and 2011 from diabetes specialists' patient registries identified variables related to prescription of different antihyp...

BACKGROUND Xanthium indicum stem is used in folk medicine of Bangladesh to control sugar in diabetic patients and to alleviate pain. The objective of the study was to evaluate antihyperglycemic and antinociceptive activity of methanolic extract of Xanthium indicum stems (XISE) in mice. METHODS Antihyperglycemic activity was measured by oral glucose tolerance tests in glucose-loaded Swiss albi...

BACKGROUND Alternanthera sessilis is used by folk medicinal practitioners of Bangladesh for alleviation of severe pain. The objective of this study was to scientifically analyze the analgesic (non-narcotic) property of aerial parts of the plant along with antihyperglycemic activity. METHODS Antihyperglycemic activity was measured by oral glucose tolerance tests. Analgesic (non-narcotic) activ...

The present study aimed to assess the hypoglycemic and antihyperglycemic activity of fruit methanolic extract of Luffa cylindrica fruits. The effect of methanolic fruit extract on oral glucose tolerance and its effect on normoglycemic rats were studied. The same was tested for antihyperglycemic activity in alloxan induced hyperglycemic rats at the two dose levels 200 and 400 mg/kg body weight p...

OBJECTIVE To investigate whether the use of incretin-based drugs (GLP-1 receptor agonists and dipeptidyl peptidase 4 [DPP4] inhibitors) is associated with acute pancreatitis. RESEARCH DESIGN AND METHODS The study was a nationwide population-based case-control study using medical databases in Denmark. Participants were 12,868 patients with a first-time hospitalization for acute pancreatitis be...

The World Health Organization recommends the use of traditional medicines, including herbs, to maintain public health and prevent treat diseases, especially chronic degenerative cancer. Traditional medicine has relatively fewer side effects than modern pharmaceutical medicine. There have been many studies that explore secondary metabolites in plants. Among them, several plant species found anti...

background: the present work was planned to evaluate the antihyperglycemic, lipid‑lowering, and antioxidant effect of lactobacillus casei and bifidobacterium bifidum in streptozotocin (stz)‑induced diabetic rats. methods: single daily dose of 1 × 107 cfu/ml of l. casei and b. bifidum alone and in combination of both was given to wistar rats orally by gavaging for 28 days. glucose tolerance test...

in an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (pocl3). the synthesized compounds were identified by 1h-nmr, 13c-nmr, ft-ir spectroscopic techniques and elemental analysis. all products were...