Despite recent research advances in anti-infective agents (achievements), Human immunodeficiency virus (HIV), and malaria infection are currently considered two main global human health problems. Given the considerable geographical overlap between malaria and HIV, a substantial number of co-infection incidences occur in human. The purpose of this review is to summarize the information on the cl...

Fungi are a newly emerging source of peptide antibiotics with therapeutic potential. Here, we report 17 new fungal defensin-like peptide (fDLP) genes and the detailed characterization of a corresponding synthetic fDLP (micasin) from a dermatophyte in terms of its structure, activity and therapeutic potential. NMR analysis showed that synthetic micasin adopts a "hallmark" cysteine-stabilized α-h...

The unfavorable effects of neonatal immunodeficiency are limited by some naturally occurring compensatory mechanisms, such as the introduction of protective and immunological components of human milk in the infant. Breast-feeding maintains the maternal-fetal immunological link after birth, may favor the transmission of immunocompetence from the mother to her infant, and is considered an importa...

Since granulocyte transfusions first became widely used in clinical medicine, there have been advances in the treatment of acute leukemia and improvement in prevention and management of infection in neutropenic patients. Improved understanding now exists concerning prognosis of infections in such patients, and advances have been made in procurement of granulocytes. Granulocyte transfusions shou...

BACKGROUND AND OBJECTIVES Hospitalized infants, children, and adolescents are typically exposed to numerous distinct medications during inpatient admissions, increasing their risk of potential drug-drug interactions (PDDIs). We assessed the prevalence and characteristics of PDDI exposure of pediatric patients treated in children's hospitals. METHODS This retrospective cohort study included pa...

Antibiotic resistance is a great burden from medicinal and economic point of view, which stems from the overprescription and misuse of anti-infective drugs. It is further aggravated by the horizontal spread of resistance genes between bacterial species and genera. The increasing rate of antibiotic resistance of bacteria urges new attempts to overcome the problem. Antimicrobial agents with new m...