In view of the effectiveness of antimalaria drugs inhibiting abnormal protease-resistant prion protein (PrP-res) formation in scrapie agent-infected cells, we tested other antimalarial compounds for similar activity. Mefloquine (MF), a quinoline antimalaria drug, was the most active compound tested against RML and 22L mouse scrapie agent-infected cells, with 50% inhibitory concentrations of app...

this study sought to determine the level of adherence to coartem© in the routine treatment of uncomplicated malaria among children under the age of five years in nyando district, kenya.seventy-three children below the age of five years with microscopically confirmed uncomplicated plasmodium falciparum malaria and prescribed coartem(®) during the normal outpatient department hours were included ...

background: resistance to most antimalarial drugs has encouraged the development of novel drugs. an alternative source for discovering such drugs is natural products. some ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. the present study is aimed to eva...

this study aimed to determine biological activity and phytochemical study of scutellaria platystegia (family labiatae). methanolic (meoh) extract of aerial parts of s. platystegia and spe fractions of methanolic extract (specially 20% and 40% methanolic fractions), growing in east-azarbaijan province of iran were found to have radical scavenging activity by dpph (2, 2-diphenyl -1- pycryl hydraz...

Malaria is one of the deadliest infectious diseases in world. Artemisinin-Based-Combination-Therapy (ACT) an antimalaria recommended by WHO, starting to experience resistance Asia. Meanwhile natural-product-immunoprotective and antimalaria-effect may benefice for malaria. Objective this study was determine effect combination ethanolic-extract from Songga-wood-stem (EESWS) ACT on IL-10, a protec...