Drug resistance is a recurrent problem in the fight against malaria. Genetic and epidemiological surveillance of antimalarial resistant parasite alleles is crucial to guide drug therapies and clinical management. New antimalarial compounds are currently at various stages of clinical trials and regulatory evaluation. Using ∼2000 Plasmodium falciparum genome sequences, we investigated the genetic...

There is an urgent need for the development of new antimalarial compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were identified. Characterization of these compounds is discussed, along with approaches to optimise the physicochemical properties. The in vitro antimalarial activity of these compounds against P. falcip...

Twenty-three aminooxy compounds have been examined for their ability to inhibit the growth of the malaria parasite Plasmodium falciparum in vitro. Eight of these compounds were found to have 50% inhibitory concentrations less than 10 microM, with the best drugs being canaline (the aminooxy analogue of ornithine) and CGP51905A at 297 +/- 23.6 nM and 242 +/- 18.8 nM, respectively. Canaline was al...

Malaria is a mosquito-borne disease caused by parasites of the genus . In humans, parasites multiply in the liver and then infect red blood cells. The life cycle consists of a sexual phase in the mosquito vector (sporogony) and an asexual phase in the vertebrate host (schizogony); both life cycle phases can be detected in assays. In general, and are the two basic approaches routinely used to ev...

Background and objectives: Aerial parts and roots of Astrodaucus persicus (Apiaceae), a native plant of Iran, were investigated. The existence of compounds with 1, 3-benzodiaxole structures has been confirmed in roots of this plant and different benzodioxole compounds have shown antimalarial and cytotoxic activities; therefore, present study has evaluated the antimalar...

malaria as one of the most recurrent infectious diseases caused by parasites of the genus plasmodium, kills several hundred thousand people especially in the tropical and subtropical regions of the world annually. terpenoids have served as the lead compounds to develop new antimalarial agents. the aromatic monoterpenoid, cuminaldehyde, isolated from the fruits of buniumpersicum was evaluated fo...

Digestion of hemoglobin in the food vacuole of the malaria parasite produces very high quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique process adopted by Plasmodium sp. to detoxify free heme. Hemozoin formation is a validated target for most of the well-known existing antimalarial drugs and considered to be a suitable target to develop new antimalarials. H...

The number of available and effective antimalarial drugs is quickly dwindling. This is mainly because a number of drug resistance-associated mutations in malaria parasite genes, such as crt, mdr1, dhfr/dhps, and others, have led to widespread resistance to all known classes of antimalarial compounds. Unfortunately, malaria parasites have started to exhibit some level of resistance in Southeast ...