نتایج جستجو برای: antimalarial drug
تعداد نتایج: 593571 فیلتر نتایج به سال:
Antimalarial drug resistance has now become a serious global challenge and is the principal reason for the decline in antimalarial drug efficacy. Malaria endemic countries need inexpensive and efficacious drugs. Preserving the life spans of antimalarial drugs is a key part of the strategy for rolling back malaria. Artemisinin-based combinations offer a new and potentially highly effective way t...
The aim of this study was to review the antimalarial drug treatment and its resistance during the course of therapy. Malaria affects the populations of tropical and subtropical areas world-wide, as well as an increasing number of travellers to these areas. Although malaria is found in over 100 countries, the major burden of disease is carried by the nations of Africa, where over 90% of all deat...
Comprehensive assessment of antimalarial drug resistance should include measurements of antimalarial blood or plasma concentrations in clinical trials and in individual assessments of treatment failure so that true resistance can be differentiated from inadequate drug exposure. Pharmacometric modeling is necessary to assess pharmacokinetic-pharmacodynamic relationships in different populations ...
26 1. Method and Search Strategy 28 2. Chloroquine 29 2.1 Mild and Moderate Adverse Effects 29 2.2 Severe Adverse Effects 30 2.3 Overdose Toxicity 30 2.4 Use in Pregnant Women 31 2.5 Use in Breast-Feeding Women 31 2.6 Contraindications and Cautions 31 3. Suifadoxine/Pyrimethamine 31 3.1 Miid and Moderate Adverse Effects 32 3.2 Severe Adverse Effects 32 3.2.1 Cutaneous Toxicity 32 3.2.2 Hepatic ...
Antimalarial drug resistance is an evolving global health security threat to malaria control. Early detection of Plasmodium falciparum resistance through therapeutic efficacy studies and associated genetic analyses may facilitate timely implementation of intervention strategies. The US President's Malaria Initiative-supported Antimalarial Resistance Monitoring in Africa Network has assisted num...
Despite the urgent need for effective antimalarial drugs with novel modes of action no new chemical class of antimalarial drug has been approved for use since 1996. To address this, we have used a rational approach to investigate compounds comprising the primary benzene sulfonamide fragment as a potential new antimalarial chemotype. We report the in vitro activity against Plasmodium falciparum ...
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